Towards a youth mental health paradigm: a perspective and roadmap
Most mental disorders have a typical onset between 12 and 25 years of age, highlighting the
importance of this period for the pathogenesis, diagnosis, and treatment of mental ill-health …
importance of this period for the pathogenesis, diagnosis, and treatment of mental ill-health …
The normative modeling framework for computational psychiatry
Normative modeling is an emerging and innovative framework for mapping individual
differences at the level of a single subject or observation in relation to a reference model. It …
differences at the level of a single subject or observation in relation to a reference model. It …
Evidence for embracing normative modeling
In this work, we expand the normative model repository introduced in Rutherford et al.,
2022a to include normative models charting lifespan trajectories of structural surface area …
2022a to include normative models charting lifespan trajectories of structural surface area …
Closing the life-cycle of normative modeling using federated hierarchical Bayesian regression
Clinical neuroimaging data availability has grown substantially in the last decade, providing
the potential for studying heterogeneity in clinical cohorts on a previously unprecedented …
the potential for studying heterogeneity in clinical cohorts on a previously unprecedented …
[HTML][HTML] Site effects how-to and when: An overview of retrospective techniques to accommodate site effects in multi-site neuroimaging analyses
Site differences, or systematic differences in feature distributions across multiple data-
acquisition sites, are a known source of heterogeneity that may adversely affect large-scale …
acquisition sites, are a known source of heterogeneity that may adversely affect large-scale …
[HTML][HTML] Warped Bayesian linear regression for normative modelling of big data
Normative modelling is becoming more popular in neuroimaging due to its ability to make
predictions of deviation from a normal trajectory at the level of individual participants. It …
predictions of deviation from a normal trajectory at the level of individual participants. It …
Population-wide cerebellar growth models of children and adolescents
C Gaiser, R van der Vliet, AAA de Boer… - Nature …, 2024 - nature.com
In the past, the cerebellum has been best known for its crucial role in motor function.
However, increasingly more findings highlight the importance of cerebellar contributions in …
However, increasingly more findings highlight the importance of cerebellar contributions in …
Revealing individual neuroanatomical heterogeneity in Alzheimer disease using neuroanatomical normative modeling
Background and Objectives Alzheimer disease (AD) is highly heterogeneous, with marked
individual differences in clinical presentation and neurobiology. To explore this, we used …
individual differences in clinical presentation and neurobiology. To explore this, we used …
[HTML][HTML] Accommodating site variation in neuroimaging data using normative and hierarchical Bayesian models
The potential of normative modeling to make individualized predictions from neuroimaging
data has enabled inferences that go beyond the case-control approach. However, site …
data has enabled inferences that go beyond the case-control approach. However, site …
Addressing global environmental challenges to mental health using population neuroscience: A review
Importance Climate change, pollution, urbanization, socioeconomic inequality, and
psychosocial effects of the COVID-19 pandemic have caused massive changes in …
psychosocial effects of the COVID-19 pandemic have caused massive changes in …