[HTML][HTML] Disruption by stealth-Interference of endocrine disrupting chemicals on hormonal crosstalk with thyroid axis function in humans and other animals

AA Thambirajah, MG Wade, J Verreault, N Buisine… - Environmental …, 2022 - Elsevier
Thyroid hormones (THs) are important regulators of growth, development, and homeostasis
of all vertebrates. There are many environmental contaminants that are known to disrupt TH …

Using in Vitro High Throughput Screening Assays to Identify Potential Endocrine-Disrupting Chemicals

DM Rotroff, DJ Dix, KA Houck… - Environmental …, 2013 - ehp.niehs.nih.gov
Background: Over the past 20 years, an increased focus on detecting environmental
chemicals that pose a risk of adverse effects due to endocrine disruption has driven the …

NTP-CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A

RE Chapin, J Adams, K Boekelheide… - … research. Part B …, 2008 - pubmed.ncbi.nlm.nih.gov
NTP-CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A
NTP-CERHR expert panel report on the reproductive and developmental toxicity of bisphenol …

A path forward in the debate over health impacts of endocrine disrupting chemicals

RT Zoeller, Å Bergman, G Becher, P Bjerregaard… - Environmental …, 2014 - Springer
Several recent publications reflect debate on the issue of “endocrine disrupting
chemicals”(EDCs), indicating that two seemingly mutually exclusive perspectives are being …

In Utero and Lactational Exposure to Bisphenol A, In Contrast to Ethinyl Estradiol, Does Not Alter Sexually Dimorphic Behavior, Puberty, Fertility, and Anatomy of …

BC Ryan, AK Hotchkiss, KM Crofton… - Toxicological …, 2010 - academic.oup.com
Many chemicals released into the environment display estrogenic activity including the oral
contraceptive ethinyl estradiol (EE2) and the plastic monomer bisphenol A (BPA). EE2 is …

[图书][B] Developmental and reproductive toxicology: a practical approach

RD Hood, RD Hood - 2005 - taylorfrancis.com
Completely revised and updated, Developmental and Reproductive Toxicology: A Practical
Approach, Second Edition draws together valuable information typically scattered …

In vitro-to-in vivo extrapolation (IVIVE) by PBTK modeling for animal-free risk assessment approaches of potential endocrine-disrupting compounds

E Fabian, C Gomes, B Birk, T Williford… - Archives of …, 2019 - Springer
While in vitro testing is used to identify hazards of chemicals, nominal in vitro assay
concentrations may misrepresent potential in vivo effects and do not provide dose–response …

A curated database of rodent uterotrophic bioactivity

NC Kleinstreuer, PC Ceger, DG Allen… - Environmental …, 2016 - ehp.niehs.nih.gov
Background: Novel in vitro methods are being developed to identify chemicals that may
interfere with estrogen receptor (ER) signaling, but the results are difficult to put into …

Gestational and lactational exposure to ethinyl estradiol, but not bisphenol A, decreases androgen-dependent reproductive organ weights and epididymal sperm …

KL Howdeshell, J Furr, CR Lambright… - Toxicological …, 2008 - academic.oup.com
Many chemicals released into the environment are capable of disrupting normal sex steroid
balance, including the oral contraceptive ethinyl estradiol (EE) and the plastic monomer …

In Vitro and In Vivo Evaluation of the Estrogenic, Androgenic, and Progestagenic Potential of Two Cyclic Siloxanes

AL Quinn, JM Regan, JM Tobin, BJ Marinik… - Toxicological …, 2007 - academic.oup.com
The purpose of these experiments was to determine the potential estrogenic, androgenic,
and progestagenic activity of two cyclic siloxanes, octamethylcyclotetrasiloxane (D4) and …