Abstract The Rho GTPases—RHOA, RAC1 and CDC42—are small GTP binding proteins
that regulate basic biological processes such as cell locomotion, cell division and …

A conserved molecular machinery centered on the Cdc42 GTPase regulates cell polarity in
diverse organisms. Here we review findings from budding and fission yeasts that reveal both …

Dynamic patterning of specific proteins is essential for the spatio-temporal regulation of
many important intracellular processes in prokaryotes, eukaryotes and multicellular …

Having a sense of direction is a fundamental cellular trait that can determine cell shape,
division orientation, or function, and ultimately the formation of a functional, multicellular …

Mathematical modeling has been instrumental in identifying common principles of cell
polarity across diverse systems. These principles include positive feedback loops that are …

Asymmetric cell division plays a crucial role in cell differentiation, unequal replicative
senescence, and stem cell maintenance. In budding yeast, the identities of mother and …

How can a self-organized cellular function evolve, adapt to perturbations, and acquire new
sub-functions? To make progress in answering these basic questions of evolutionary cell …

Polarization is a fundamental cellular property, which is essential for the function of
numerous cell types. Over the past three to four decades, research using the best …

Mitogen-activated protein kinase (MAPK) pathways are conserved from yeast to man and
regulate a variety of cellular processes, including proliferation and differentiation. Recent …

The development of organisms starting from their zygotic state involves a tight integration of
the myriad biochemical signaling interactions with the mechanical forces that eventually …