CCDC (coiled-coil domain-containing) is a coiled helix domain that exists in natural proteins.
There are about 180 CCDC family genes, encoding proteins that are involved in intercellular …

Extracellular vesicles (EVs) are spherical bilayer membrane vesicles released by cells into
extracellular spaces and body fluids, including plasma and synovial fluid. EV cargo …

Previous studies have demonstrated that tumor-associated macrophages (TAMs) exhibiting
an M2 phenotype contribute significantly to the pathogenesis of various cancer types …

Background The progression of non-small cell lung cancer (NSCLC) is significantly
influenced by circular RNAs (circRNAs), especially in tumor hypoxia microenvironment …

Tumor progression of colorectal cancer (CRC) seriously affects patient prognosis. For CRC
patients with advanced-stage disease, it is still necessary to continuously explore more …

Osteoarthritis (OA) is a common chronic degenerative joint disease worldwide. The
pathological features of OA are the erosion of articular cartilage, subchondral bone …

Osteoarthritis (OA) is a prevalent chronic degenerative joint disease worldwide. Obesity has
been linked to OA, and increased free fatty acid levels (eg, palmitate) contribute to …

Radiotherapy is a major therapeutic strategy for lung cancer, and radiation resistance
(radioresistance) is an important cause of residual and recurring cancer after treatment …

Wnt/β-catenin signaling is a critical pathway that influences development and therapeutic
response of non-small cell lung cancer (NSCLC). In recent years, many Wnt regulators …

Low-density lipoprotein receptor-related protein 8 (LRP8) is involved in the development of
multiple tumors, including lung cancer. However, the exact mechanism by which LRP8 …