Inflammation and liver cancer: molecular mechanisms and therapeutic targets
Hepatocellular carcinoma (HCC) is associated with chronic inflammation and fibrosis arising
from different etiologies, including hepatitis B and C and alcoholic and nonalcoholic fatty …
from different etiologies, including hepatitis B and C and alcoholic and nonalcoholic fatty …
Immunomodulatory role of the extracellular matrix within the liver disease microenvironment
CE McQuitty, R Williams, S Chokshi… - Frontiers in …, 2020 - frontiersin.org
Chronic liver disease when accompanied by underlying fibrosis, is characterized by an
accumulation of extracellular matrix (ECM) proteins and chronic inflammation. Although …
accumulation of extracellular matrix (ECM) proteins and chronic inflammation. Although …
[HTML][HTML] Epidemiology and pathophysiology of the association between NAFLD and metabolically healthy or metabolically unhealthy obesity
The prevalence of nonalcoholic fatty liver disease (NAFLD) is continuing to rise in many
countries, paralleling the epidemic of obesity worldwide. In the last years, the concept of …
countries, paralleling the epidemic of obesity worldwide. In the last years, the concept of …
[HTML][HTML] Hepatic stellate cell activation and senescence induced by intrahepatic microbiota disturbances drive progression of liver cirrhosis toward hepatocellular …
B Liu, Z Zhou, Y Jin, J Lu, D Feng, R Peng… - … for Immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Background The significance of the relationship between the microbiota and diseases is
increasingly being recognized. However, the characterization of tumor microbiome and their …
increasingly being recognized. However, the characterization of tumor microbiome and their …
Tenascin-C in cardiac disease: a sophisticated controller of inflammation, repair, and fibrosis
K Imanaka-Yoshida, I Tawara… - American Journal of …, 2020 - journals.physiology.org
Tenascin-C (TNC) is a large extracellular matrix glycoprotein classified as a matricellular
protein that is generally upregulated at high levels during physiological and pathological …
protein that is generally upregulated at high levels during physiological and pathological …
[HTML][HTML] Metformin regulates inflammation and fibrosis in diabetic kidney disease through TNC/TLR4/NF-κB/miR-155-5p inflammatory loop
Y Zhou, XY Ma, JY Han, M Yang, C Lv… - World journal of …, 2021 - ncbi.nlm.nih.gov
BACKGROUND Type 2 diabetes mellitus (T2DM) is significantly increasing worldwide, and
the incidence of its complications is also on the rise. One of the main complications of T2DM …
the incidence of its complications is also on the rise. One of the main complications of T2DM …
Internal affairs: tenascin-C as a clinically relevant, endogenous driver of innate immunity
AM Marzeda, KS Midwood - Journal of Histochemistry & …, 2018 - journals.sagepub.com
To protect against danger, the innate immune system must promptly and accurately sense
alarm signals, and mount an appropriate response to restore homeostasis. One …
alarm signals, and mount an appropriate response to restore homeostasis. One …
Extracellular vesicles: an emerging mechanism governing the secretion and biological roles of tenascin-C
L Albacete-Albacete, M Sánchez-Álvarez… - Frontiers in …, 2021 - frontiersin.org
ECM composition and architecture are tightly regulated for tissue homeostasis. Different
disorders have been associated to alterations in the levels of proteins such as collagens …
disorders have been associated to alterations in the levels of proteins such as collagens …
Tenascin-c in heart diseases—The role of inflammation
K Imanaka-Yoshida - International Journal of Molecular Sciences, 2021 - mdpi.com
Tenascin-C (TNC) is a large extracellular matrix (ECM) glycoprotein and an original member
of the matricellular protein family. TNC is transiently expressed in the heart during embryonic …
of the matricellular protein family. TNC is transiently expressed in the heart during embryonic …
Tenascin-C function in glioma: immunomodulation and beyond
First identified in the 1980s, tenascin-C (TNC) is a multi-domain extracellular matrix
glycoprotein abundantly expressed during the development of multicellular organisms. TNC …
glycoprotein abundantly expressed during the development of multicellular organisms. TNC …