Emerging principles of cytokine pharmacology and therapeutics

RA Saxton, CR Glassman, KC Garcia - Nature Reviews Drug Discovery, 2023 - nature.com
Cytokines are secreted signalling proteins that play essential roles in the initiation,
maintenance and resolution of immune responses. Although the unique ability of cytokines …

[HTML][HTML] Erythropoietin regulation of red blood cell production: From bench to bedside and back

SV Bhoopalan, LJ Huang, MJ Weiss - F1000Research, 2020 - ncbi.nlm.nih.gov
More than 50 years of efforts to identify the major cytokine responsible for red blood cell
(RBC) production (erythropoiesis) led to the identification of erythropoietin (EPO) in 1977 …

Erythropoietin as a neuroprotective molecule: an overview of its therapeutic potential in neurodegenerative diseases

F Rey, A Balsari, T Giallongo, S Ottolenghi… - ASN …, 2019 - journals.sagepub.com
Erythropoietin (EPO) is a cytokine mainly induced in hypoxia conditions. Its major production
site is the kidney. EPO primarily acts on the erythroid progenitor cells in the bone marrow …

[HTML][HTML] Treatment of neonatal hypoxic-ischemic encephalopathy with erythropoietin alone, and erythropoietin combined with hypothermia: history, current status, and …

DE Oorschot, RJ Sizemore, AR Amer - International journal of molecular …, 2020 - mdpi.com
Perinatal hypoxic-ischemic encephalopathy (HIE) remains a major cause of morbidity and
mortality. Moderate hypothermia (33.5° C) is currently the sole established standard …

[HTML][HTML] Erythropoietin as a neuroprotective drug for newborn infants: ten years after the first use

S Perrone, C Lembo, F Gironi, C Petrolini, T Catalucci… - Antioxidants, 2022 - mdpi.com
Protective strategies against perinatal brain injury represent a major challenge for modern
neonatology. Erythropoietin (Epo) enhances endogenous mechanisms of repair and …

An update on the cardiac effects of erythropoietin cardioprotection by erythropoietin and the lessons learnt from studies in neuroprotection

MA Bogoyevitch - Cardiovascular research, 2004 - academic.oup.com
Erythropoietin (Epo) was once thought to act exclusively in the formation of red blood cells.
As recently reviewed by Smith et al.[Cardiovasc. Res. 59 (2003) 538–548], Epo can also act …

The promises and challenges of erythropoietin for treatment of Alzheimer's disease

J Sun, JM Martin, V Vanderpoel, RK Sumbria - Neuromolecular medicine, 2019 - Springer
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder in the world, and
intracellular neurofibrillary tangles and extracellular amyloid-beta protein deposits represent …

Optimizing detection of erythropoietin receptor agonists from dried blood spots for anti‐doping application

CE Heiland, M Ericsson, A Pohanka… - Drug testing and …, 2022 - Wiley Online Library
Abstract The World Anti‐Doping Agency (WADA) has recently implemented dried blood
spots (DBSs) as a matrix for doping control. However, specifications regarding the analysis …

Achieving routine application of dried blood spots for erythropoietin receptor agonist analysis in doping control: low-volume single-spot detection at minimum required …

L Requena-Tutusaus, I Anselmo, É Alechaga… - Bioanalysis, 2023 - Taylor & Francis
Abstract Background: Erythropoietin receptor agonists (ERAs) are substances prohibited in
sports and currently monitored in urine and blood. There is a great interest in new matrices …

Chemokine receptor antagonists: a novel therapeutic approach in allergic diseases

J Elsner, SE Escher, U Forssmann - Allergy, 2004 - Wiley Online Library
The aim of this review is to give an overview of the role of chemokines, particularly ligands of
the CC chemokine receptor CCR3, in allergic diseases and to show the new concept in the …