Organoselenium and organotellurium compounds: toxicology and pharmacology

CW Nogueira, G Zeni, JBT Rocha - Chemical reviews, 2004 - ACS Publications
Organoselenium compounds have found such wide utility because of their effects on an
extraordinary number of very different reactions, including many carbon-carbon bond …

Toxicology and pharmacology of selenium: emphasis on synthetic organoselenium compounds

CW Nogueira, JBT Rocha - Archives of Toxicology, 2011 - Springer
The advance in the area of synthesis and reactivity of organoselenium, as well as the
discovery that selenium was the cause of severe intoxication episodes of livestock in the …

Organoselenium compounds as mimics of selenoproteins and thiol modifier agents

NV Barbosa, CW Nogueira, PA Nogara… - Metallomics, 2017 - academic.oup.com
Selenium is an essential trace element for animals and its role in the chemistry of life relies
on a unique functional group: the selenol (–SeH) group. The selenol group participates in …

[HTML][HTML] Diphenyl diselenide a janus-faced molecule

CW Nogueira, JBT Rocha - Journal of the Brazilian Chemical Society, 2010 - SciELO Brasil
In this review, we summarized the potential role of synthetic organoseleno compounds as
therapeutic or toxic agents, giving emphasis almost exclusively to diphenyl diselenide, the …

Aminolevulinate dehydratase (δ-ALA-D) as marker protein of intoxication with metals and other pro-oxidant situations

JBT Rocha, RA Saraiva, SC Garcia… - Toxicology …, 2012 - academic.oup.com
Abstract δ-ALA-D is a metalloenzyme that has 3 vicinal thiol/thiolate groups that coordinate
with Zn (ii). The proximity between the sulfhydryl groups renders δ-ALA-D extremely …

Mechanistic Insight into the Oxidation of Organic Phenylselenides by H2O2

G Ribaudo, M Bellanda, I Menegazzo… - … A European Journal, 2017 - Wiley Online Library
The oxidation of organic phenylselenides by H2O2 is investigated in model compounds,
namely, n‐butyl phenyl selenide (PhSe (nBu)), bis (phenylselanyl) methane (PhSeMeSePh) …

Insights on selenium and tellurium diaryldichalcogenides: A benchmark DFT study

F Zaccaria, LP Wolters… - Journal of …, 2016 - Wiley Online Library
Selenium based diaryl dichalcogenides are compounds that are receiving attention in
organic synthesis as eco‐friendly oxidation agents as well as in pharmaceutical chemistry …

Reduction of diphenyl diselenide and analogs by mammalian thioredoxin reductase is independent of their gluthathione peroxidase-like activity: a possible novel …

AS Freitas, AS Prestes, C Wagner, JH Sudati, D Alves… - Molecules, 2010 - mdpi.com
Since the successful use of the organoselenium drug ebselen in clinical trials for the
treatment of neuropathological conditions associated with oxidative stress, there have been …

Organodiselenides: Organic catalysis and drug design learning from glutathione peroxidase

MD Tiezza, G Ribaudo, L Orian - Current Organic Chemistry, 2019 - ingentaconnect.com
Organodiselenides are an important class of compounds characterized by the presence of
two adjacent covalently bonded selenium nuclei. Among them, diaryldiselenides and their …

Trans-sulfuration pathway seleno-amino acids are mediators of selenomethionine toxicity in Saccharomyces cerevisiae

M Lazard, M Dauplais, S Blanquet, P Plateau - Journal of Biological …, 2015 - ASBMB
Toxicity of selenomethionine, an organic derivative of selenium widely used as supplement
in human diets, was studied in the model organism Saccharomyces cerevisiae. Several …