Mapping human brain function is a long-standing goal of neuroscience that promises to
inform the development of new treatments for brain disorders. Early maps of human brain …

Executive control is a complex high-level cognitive function that relies on distributed brain
circuitry. We propose that the anterior insular cortex plays an under-appreciated role in …

Recent advancements in computational approaches and neuroimaging techniques have
refined our understanding of the precuneus. While previously believed to be largely a visual …

Multimodal evidence suggests that brain regions accumulate information over timescales
that vary according to anatomical hierarchy. Thus, these experimentally defined “temporal …

The understanding and treatment of psychiatric disorders, which are known to be
neurobiologically and clinically heterogeneous, could benefit from the data-driven …

Depression is a heterogeneous and etiologically complex psychiatric syndrome, not a
unitary disease entity, encompassing a broad spectrum of psychopathology arising from …

The brain is constantly bombarded by stimuli, and the relative salience of these inputs
determines which are more likely to capture attention. A brain system known as the'salience …

Transcranial magnetic stimulation (TMS) is an effective treatment for depression but is
limited in that the optimal therapeutic target remains unknown. Early TMS trials lacked a …

Antidepressants are widely prescribed, but their efficacy relative to placebo is modest, in part
because the clinical diagnosis of major depression encompasses biologically …

The intuitive association between self-focused rumination in major depressive disorder
(MDD) and the self-referential operations performed by the brain's default-mode network …