The observation and analysis of intra-tumour heterogeneity (ITH), particularly in genomic
studies, has advanced our understanding of the evolutionary forces that shape cancer …

Histological and molecular analyses of urothelial carcinoma often reveal intratumoural and
intertumoural heterogeneity at the genomic, transcriptional and cellular levels. Despite the …

Minimally invasive approaches to detect residual disease after surgery are needed to
identify patients with cancer who are at risk for metastatic relapse. Circulating tumour DNA …

Background Muscle-invasive bladder cancer (MIBC) is a molecularly diverse disease with
heterogeneous clinical outcomes. Several molecular classifications have been proposed …

The extent of somatic mutation and clonal selection in the human bladder remains unknown.
We sequenced 2097 bladder microbiopsies from 20 individuals using targeted (n= 1914 …

PURPOSE Novel sensitive methods for early detection of relapse and for monitoring
therapeutic efficacy may have a huge impact on risk stratification, treatment, and ultimately …

Bladder cancer is a common malignancy that has a relatively poor outcome. Lack of culture
models for the bladder epithelium (urothelium) hampers the development of new …

Molecular subtyping may inform on prognosis and treatment response in bladder cancer.
However, intratumoral molecular heterogeneity is not well studied in this disease and could …

Knowledge of somatic mutation accumulation in normal cells, which is essential for
understanding cancer development and evolution, remains largely lacking. In this study, we …

Purpose: To characterize immune cell expression among patients with non–muscle invasive
bladder cancer (NMIBC) treated with Bacillus Calmette-Guerin (BCG). Experimental Design …