Therapeutic anti‐amyloid β antibodies cause neuronal disturbances

UK Adhikari, R Khan, M Mikhael, R Balez… - Alzheimer's & …, 2023 - Wiley Online Library
Introduction Recent published clinical trial safety data showed that 41% of Alzheimer
patients experienced amyloid‐related imaging abnormalities (ARIA), marks of …

[HTML][HTML] Deciphering the impact of aging on splenic endothelial cell heterogeneity and immunosenescence through single-cell RNA sequencing analysis

Y Huang, Z Liu, M Li, D Wang… - Immunity & …, 2024 - immunityageing.biomedcentral.com
Aging is associated with significant structural and functional changes in the spleen, leading
to immunosenescence, yet the detailed effects on splenic vascular endothelial cells (ECs) …

FibroAtlas: a database for the exploration of fibrotic diseases and their genes

J Liu, D Sun, J Liu, H Xu, Y Liu, Y Li… - Cardiology …, 2019 - Wiley Online Library
Background. Fibrosis is a highly dynamic process caused by prolonged injury, deregulation
of the normal processes of wound healing, and extensive deposition of extracellular matrix …

Cross-linking cellular prion protein induces neuronal type 2-like hypersensitivity

UK Adhikari, E Sakiz, X Zhou, U Habiba… - Frontiers in …, 2021 - frontiersin.org
Background Previous reports identified proteins associated with 'apoptosis' following cross-
linking PrPC with motif-specific anti-PrP antibodies in vivo and in vitro. The molecular …

ILDGDB: a manually curated database of genomics, transcriptomics, proteomics and drug information for interstitial lung diseases

Y Li, G Wu, Y Shang, Y Qi, X Wang, S Ning… - BMC Pulmonary …, 2020 - Springer
Abstract Background Interstitial lung diseases (ILDs), a diverse group of diffuse lung
diseases, mainly affect the lung parenchyma. The low-throughput 'omics' technologies …

MicroRNA profiling of the tears of children with vernal keratoconjunctivitis

NH Syed, WNS Shahidan, I Shatriah… - Frontiers in Genetics, 2022 - frontiersin.org
Vernal Keratoconjunctivitis (VKC) is a chronic conjunctival inflammatory condition that
typically affects children. Extracellular microRNAs (miRNAs) are small noncoding RNA …

Multi-method molecular characterisation of human dust-mite-associated allergic asthma

E Whittle, MO Leonard, TW Gant, DP Tonge - Scientific Reports, 2019 - nature.com
Asthma is a chronic inflammatory disorder of the airways. Disease presentation varies
greatly in terms of cause, development, severity, and response to medication, and thus the …

Integration of multi-source gene interaction networks and omics data with graph attention networks to identify novel disease genes

K Yang, J Cheng, S Cao, X Pan, H Shen, C Jin, Y Yuan - bioRxiv, 2023 - biorxiv.org
The pathogenesis of diseases is closely associated with genes, and the discovery of
disease genes holds significant importance for understanding disease mechanisms and …

DAAB‐V2: Updated database of allergy and asthma biomarkers.

S Majumdar, S Bhattacharjee, T Jana, S Saha - Allergy, 2021 - search.ebscohost.com
Keywords: allergy and asthma; biomarkers; regulatory network; relational database; single
nucleotide polymorphisms EN allergy and asthma biomarkers regulatory network relational …

UVGD 1.0: a gene-centric database bridging ultraviolet radiation and molecular biology effects in organisms

H Xu, Y Wang, L Diao, X Wang, Y Zhang… - … Journal of Radiation …, 2019 - Taylor & Francis
Objectives: Exposing to ultraviolet for a certain time will trigger some significant molecular
biology effects in an organism. In the past few decades, varied ultraviolet-associated …