Notch signaling is an evolutionarily highly conserved signaling mechanism, but in contrast to
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …

Cerebral autosomal dominant arteriopathy with subcortical infarcts and
leucoencephalopathy (CADASIL) is the most common heritable cause of stroke and …

Notch signaling regulates a vast array of crucial developmental processes. It is therefore not
surprising that mutations in genes encoding Notch receptors or ligands lead to a variety of …

Cerebral ischemic small vessel disease (SVD) is the leading cause of vascular dementia
and a major contributor to stroke in humans. Dominant mutations in NOTCH3 cause cerebral …

Notch signaling is an ancient intercellular signaling mechanism that plays myriad roles
during vascular development and physiology in vertebrates. These roles include regulation …

CADASIL and CARASIL are hereditary small vessel diseases leading to vascular dementia.
CADASIL commonly begins with migraine followed by minor strokes in mid‐adulthood …

Notch signaling is an evolutionarily conserved, intercellular signaling mechanism that plays
myriad roles during vascular development and physiology in vertebrates. These roles …

Signals through the Notch receptors are used throughout development to control cellular
fate choices. Our intention here is to provide an overview of the involvement of Notch …

Cerebral autosomal dominant arteriopathy with subcortical infarcts and
leukoencephalopathy, or CADASIL, one of the most common inherited small vessel …

Notch signaling is critically important for proper architecture of the vascular system, and
mutations in NOTCH3 are associated with CADASIL, a stroke and dementia syndrome with …