Opening doors with ultrasound and microbubbles: Beating biological barriers to promote drug delivery

J Deprez, G Lajoinie, Y Engelen, SC De Smedt… - Advanced drug delivery …, 2021 - Elsevier
Apart from its clinical use in imaging, ultrasound has been thoroughly investigated as a tool
to enhance drug delivery in a wide variety of applications. Therapeutic ultrasound, as such …

[HTML][HTML] Translating complexity and heterogeneity of pancreatic tumor: 3D in vitro to in vivo models

MA Heinrich, AMRH Mostafa, JP Morton… - Advanced drug delivery …, 2021 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive type of cancer with
an overall survival rate of less than 7-8%, emphasizing the need for novel effective …

Ultrasound nanotheranostics: Toward precision medicine

Y Qin, X Geng, Y Sun, Y Zhao, W Chai, X Wang… - Journal of Controlled …, 2023 - Elsevier
Ultrasound (US) is a mechanical wave that can penetrate biological tissues and trigger
complex bioeffects. The mechanisms of US in different diagnosis and treatment are different …

[HTML][HTML] Barrier-breaking effects of ultrasonic cavitation for drug delivery and biomarker release

Y Hu, J Wei, Y Shen, S Chen, X Chen - Ultrasonics Sonochemistry, 2023 - Elsevier
Recently, emerging evidence has demonstrated that cavitation actually creates important
bidirectional channels on biological barriers for both intratumoral drug delivery and …

CO2-Driven Nebulization of pH-Sensitive Supramolecular Polymers for Intraperitoneal Hydrogel Formation and the Treatment of Peritoneal Metastasis

H Braet, PP Fransen, R Mariën, G Lollo… - … Applied Materials & …, 2023 - ACS Publications
Because peritoneal metastasis (PM) from ovarian cancer is characterized by non-specific
symptoms, it is often diagnosed at advanced stages. Pressurized intraperitoneal aerosol …

Application of ultrasound combined with microbubbles for cancer therapy

D Sharma, KX Leong, GJ Czarnota - International Journal of Molecular …, 2022 - mdpi.com
At present, cancer is one of the leading causes of death worldwide. Treatment failure
remains one of the prime hurdles in cancer treatment due to the metastatic nature of cancer …

[HTML][HTML] Ultrasound-triggered therapeutic microbubbles enhance the efficacy of cytotoxic drugs by increasing circulation and tumor drug accumulation and limiting …

N Ingram, LE McVeigh, RH Abou-Saleh, J Maynard… - Theranostics, 2020 - ncbi.nlm.nih.gov
Most cancer patients receive chemotherapy at some stage of their treatment which makes
improving the efficacy of cytotoxic drugs an ongoing and important goal. Despite large …

Bridging smart nanosystems with clinically relevant models and advanced imaging for precision drug delivery

Q Zhou, Q Liu, Y Wang, J Chen, O Schmid… - Advanced …, 2024 - Wiley Online Library
Intracellular delivery of nano‐drug‐carriers (NDC) to specific cells, diseased regions, or
solid tumors has entered the era of precision medicine that requires systematic knowledge …

[HTML][HTML] High-throughput microfluidics for evaluating microbubble enhanced delivery of cancer therapeutics in spheroid cultures

MD Bourn, DVB Batchelor, N Ingram… - Journal of Controlled …, 2020 - Elsevier
Drug penetration into solid tumours remains a major challenge in the effective treatment of
cancer. Microbubble (MB) mediated sonoporation offers a potential solution to this by …

Monodisperse versus polydisperse ultrasound contrast agents: In vivo sensitivity and safety in rat and pig

A Helbert, E Gaud, T Segers, C Botteron… - Ultrasound in Medicine …, 2020 - Elsevier
Recent advances in the field of monodisperse microbubble synthesis by flow focusing allow
for the production of foam-free, highly concentrated and monodisperse lipid-coated …