Balancing repair and tolerance of DNA damage caused by alkylating agents
Alkylating agents constitute a major class of frontline chemotherapeutic drugs that inflict
cytotoxic DNA damage as their main mode of action, in addition to collateral mutagenic …
cytotoxic DNA damage as their main mode of action, in addition to collateral mutagenic …
The many functions of APE1/Ref-1: not only a DNA repair enzyme
G Tell, F Quadrifoglio, C Tiribelli… - Antioxidants & redox …, 2009 - liebertpub.com
Abstract APE1/Ref-1 (APE1), the mammalian ortholog of Escherichia coli Xth, and a
multifunctional protein possessing both DNA repair and transcriptional regulatory activities …
multifunctional protein possessing both DNA repair and transcriptional regulatory activities …
Sorafenib resistance in hepatocellular carcinoma: the relevance of genetic heterogeneity
Despite advances in biomedicine, the incidence and the mortality of hepatocellular
carcinoma (HCC) remain high. The majority of HCC cases are diagnosed in later stages …
carcinoma (HCC) remain high. The majority of HCC cases are diagnosed in later stages …
Human apurinic/apyrimidinic endonuclease 1
M Li, DM Wilson III - Antioxidants & redox signaling, 2014 - liebertpub.com
Significance: Human apurinic/apyrimidinic endonuclease 1 (APE1, also known as REF-1)
was isolated based on its ability to cleave at AP sites in DNA or activate the DNA binding …
was isolated based on its ability to cleave at AP sites in DNA or activate the DNA binding …
APE1/Ref-1 as an emerging therapeutic target for various human diseases: phytochemical modulation of its functions
Abstract Apurinic/apyrimidinic endonuclease 1 (APE1) is a multifunctional enzyme involved
in the base excision repair (BER) pathway, which repairs oxidative base damage caused by …
in the base excision repair (BER) pathway, which repairs oxidative base damage caused by …
Human AP endonuclease 1 (APE1): from mechanistic insights to druggable target in cancer
R Abbotts, S Madhusudan - Cancer treatment reviews, 2010 - Elsevier
DNA base excision repair (BER) is critically involved in the processing of DNA base damage
induced by alkylating agents. Pharmacological inhibition of BER (using PARP inhibitors) …
induced by alkylating agents. Pharmacological inhibition of BER (using PARP inhibitors) …
Exploiting the Ref-1-APE1 node in cancer signaling and other diseases: from bench to clinic
F Shah, D Logsdon, RA Messmann… - NPJ precision …, 2017 - nature.com
Abstract Reduction-oxidation factor 1-apurinic/apyrimidinic endonuclease (Ref-1/APE1) is a
critical node in tumor cells, both as a redox regulator of transcription factor activation and as …
critical node in tumor cells, both as a redox regulator of transcription factor activation and as …
APE1/Ref-1role in redox signaling: translational applications of targeting the redox function of the DNA repair/redox protein APE1/Ref-1
MR Kelley, MM Georgiadis… - Current molecular …, 2012 - ingentaconnect.com
The heterogeneity of most cancers diminishes the treatment effectiveness of many cancer-
killing regimens. Thus, treatments that hold the most promise are ones that block multiple …
killing regimens. Thus, treatments that hold the most promise are ones that block multiple …
Graphene quantum dot-based nanocomposites for diagnosing cancer biomarker APE1 in living cells
H Zhang, S Ba, Z Yang, T Wang, JY Lee… - … applied materials & …, 2020 - ACS Publications
As an essential DNA repair enzyme, apurinic/apyrimidinic endonuclease 1 (APE1) is
overexpressed in most human cancers and is identified as a cancer diagnostic and …
overexpressed in most human cancers and is identified as a cancer diagnostic and …
Probing and regulating the activity of cellular enzymes by using DNA tetrahedron nanostructures
Given the essential role of apurinic/apyrimidinic endonuclease (APE1) in gene repair and
cancer progression, we report a novel approach for probing and regulating cellular APE1 …
cancer progression, we report a novel approach for probing and regulating cellular APE1 …