Nearly 15 types of programmed cell death (PCD) have been identified to date. Among them,
apoptosis is the most common and well-studied type of PCD. In this review, we discuss …

Caspases belong to a diverse clan of proteolytic enzymes known as clan CD with highly
disparate functions in cell signaling. The caspase members of this clan are only found in …

In prokaryotes, CRISPR-Cas systems provide adaptive immune responses against foreign
genetic elements through RNA-guided nuclease activity. Recently, additional genes with …

Abstract The type III-E CRISPR–Cas system uses a single multidomain effector called Cas7-
11 (also named gRAMP) to cleave RNA and associate with a caspase-like protease Csx29 …

Posttranslational modifications are an important feature of most proteases in higher
organisms, such as the conversion of inactive zymogens into active proteases. To date, little …

The phenotypic and biochemical similarities between caspase-mediated apoptosis and
cellular differentiation are striking. They include such diverse phenomenon as mitochondrial …

This review aims to highlight the proteases required for regulated cell death mechanisms in
animals and plants. The aim is to be incisive, and not inclusive of all the animal proteases …

Caspase is a well-studied metazoan protease involved in programmed cell death and
immunity in animals. Obviously, homologues of caspases with evolutionarily similar …

Initially found to be critically involved in inflammation and apoptosis, caspases have since
then been implicated in the regulation of various signaling pathways in animals. How …

Caspases are a highly conserved family of cysteine-aspartyl proteases known for their
essential roles in regulating apoptosis, inflammation, cell differentiation, and proliferation …