Pathogen diversity, immunity, and the fate of infections: lessons learned from Trypanosoma cruzi human–host interactions

LMD Magalhães, KJ Gollob, B Zingales… - The Lancet …, 2022 - thelancet.com
The complexity of host–pathogen interactions often leads to distinct clinical outcomes upon
infection with different pathogen strains. In this Review, we explore the interactions between …

Current research of trichinellosis in China

X Bai, X Hu, X Liu, B Tang, M Liu - Frontiers in Microbiology, 2017 - frontiersin.org
Trichinellosis, caused by Trichinella, is an emerging or re-emerging zoonotic parasitic
disease, which is distributed worldwide with major socio-economic importance in some …

[HTML][HTML] Autoimmune pathogenesis of Chagas heart disease: looking back, looking ahead

KM Bonney, DM Engman - The American journal of pathology, 2015 - Elsevier
Chagas heart disease is an inflammatory cardiomyopathy that develops in approximately
one-third of individuals infected with the protozoan parasite Trypanosoma cruzi. Since the …

[HTML][HTML] Chagas disease vaccine design: the search for an efficient Trypanosoma cruzi immune-mediated control

AE Bivona, AS Alberti, N Cerny, SN Trinitario… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Chagas disease is currently endemic to 21 Latin-American countries and has also become a
global concern because of globalization and mass migration of chronically infected …

Harnessing RNA technology to advance therapeutic vaccine antigens against chagas disease

C Mancino, J Pollet, A Zinger, KM Jones… - … Applied Materials & …, 2024 - ACS Publications
Chagas disease (CD)(American trypanosomiasis caused by Trypanosoma cruzi) is a
parasitic disease endemic in 21 countries in South America, with increasing global spread …

[PDF][PDF] Status of vaccine research and development of vaccines for Chagas disease

CM Beaumier, PM Gillespie, U Strych, T Hayward… - Vaccine, 2016 - core.ac.uk
An estimated 7–8 million people are infected worldwide with almost all of the cases
occurring in the Americas, predominantly in the poorest countries in the region [2–4] …

The case for the development of a Chagas disease vaccine: why? How? When?

E Dumonteil, C Herrera - Tropical Medicine and Infectious Disease, 2021 - mdpi.com
Chagas disease is a major neglected tropical disease, transmitted predominantly by
triatomine insect vectors, but also through congenital and oral routes. While endemic in the …

Experimental vaccines against Chagas disease: a journey through history

O Rodríguez-Morales… - Journal of …, 2015 - Wiley Online Library
Chagas disease, or American trypanosomiasis, which is caused by the protozoan parasite
Trypanosoma cruzi, is primarily a vector disease endemic in 21 Latin American countries …

Engineered trivalent immunogen adjuvanted with a STING agonist confers protection against Trypanosoma cruzi infection

A Sanchez Alberti, AE Bivona, N Cerny, K Schulze… - npj Vaccines, 2017 - nature.com
The parasite Trypanosoma cruzi is the causative agent of Chagas disease, a potentially life-
threatening infection that represents a major health problem in Latin America. Several …

Oral Vaccination with Attenuated Salmonella typhimurium-Delivered TsPmy DNA Vaccine Elicits Protective Immunity against Trichinella spiralis in BALB/c Mice

L Wang, X Wang, K Bi, X Sun, J Yang… - PLoS Neglected …, 2016 - journals.plos.org
Background Our previous studies showed that Trichinella spiralis paramyosin (Ts Pmy) is an
immunomodulatory protein that inhibits complement C1q and C8/C9 to evade host …