The recent boom in microfluidics and combinatorial indexing strategies, combined with low
sequencing costs, has empowered single-cell sequencing technology. Thousands—or even …

To a large extent, cancer conforms to evolutionary rules defined by the rates at which clones
mutate, adapt and grow. Next-generation sequencing has provided a snapshot of the …

Modulation of chromatin structure via histone modification is a major epigenetic mechanism
and regulator of gene expression. However, the contribution of chromatin features to tumor …

Intratumor heterogeneity, which fosters tumor evolution, is a key challenge in cancer
medicine. Here, we review data and technologies that have revealed intra-tumor …

Cancer is a leading cause of death worldwide. Identifying the best treatment using
computational models to personalize drug response prediction holds great promise to …

The fundamental operative unit of a cancer is the genetically and epigenetically innovative
single cell. Whether proliferating or quiescent, in the primary tumour mass or disseminated …

Intratumor heterogeneity has been widely reported in human cancers, but our knowledge of
how this genetic diversity emerges over time remains limited. A central challenge in studying …

BACKGROUND Elucidating the genetic architecture of neuropsychiatric disorders remains a
major scientific and medical challenge. Emerging genomic technologies now permit the …

We performed phylogenetic analysis of high-grade serous ovarian cancers (68 samples
from seven patients), identifying constituent clones and quantifying their relative …

Over the last decade, precision medicine and immunotherapeutic approaches have become
increasingly popular in oncology. Early clinical trials reported promising results, but …