Autosomal recessive primary microcephaly (MCPH) is a neurodevelopmental disorder that
is characterised by microcephaly present at birth and non-progressive mental retardation …

The centrosome was discovered in the late 19th century when mitosis was first described.
Long recognized as a key organelle of the spindle pole, its core component, the centriole …

One of the most notable trends in mammalian evolution is the massive increase in size of the
cerebral cortex, especially in primates. Humans with autosomal recessive primary …

The IQ motif is widely distributed in both myosins and non-myosins and is quite common in
the database that includes more than 900 Pfam entries. An examination of IQ motif …

The formation of a metaphase spindle, a bipolar microtubule array with centrally aligned
chromosomes, is a prerequisite for the faithful segregation of a cell's genetic material. Using …

Autosomal recessive primary microcephaly (MCPH) is a neurodevelopmental disorder. It is
characterized by two principal features, microcephaly present at birth and nonprogressive …

Genes associated with human microcephaly, a condition characterized by a small brain,
include critical regulators of proliferation, cell fate and DNA repair. We describe a syndrome …

ASPM (known as Asp in fly and ASPM-1 in worm) is a microcephaly-associated protein
family that regulates spindle architecture, but the underlying mechanism is poorly …

When the first mutant allele of the Drosophila gene polo was first characterized over 10
years ago, attention focused on the defects that centrosome behavior exhibited at various …

The translationally controlled protein P23 was discovered by the early induction of its rate of
synthesis after mitogenic stimulation of mouse fibroblasts. P23 is expressed in almost all …