[HTML][HTML] The role of lung macrophages in chronic obstructive pulmonary disease

J Wu, X Zhao, C Xiao, G Xiong, X Ye, L Li, Y Fang… - Respiratory …, 2022 - Elsevier
Chronic obstructive pulmonary disease (COPD) as a common, preventable and treatable
chronic respiratory disease in clinic, gets continuous deterioration and we can't take effective …

[HTML][HTML] Systemic alterations in neutrophils and their precursors in early-stage chronic obstructive pulmonary disease

TS Kapellos, K Baßler, W Fujii, C Nalkurthi, AC Schaar… - Cell reports, 2023 - cell.com
Systemic inflammation is established as part of late-stage severe lung disease, but
molecular, functional, and phenotypic changes in peripheral immune cells in early disease …

Tobacco smoke exposure recruits inflammatory airspace monocytes that establish permissive lung niches for Mycobacterium tuberculosis

B Corleis, CN Tzouanas, MH Wadsworth… - Science translational …, 2023 - science.org
Tobacco smoking doubles the risk of active tuberculosis (TB) and accounts for up to 20% of
all active TB cases globally. How smoking promotes lung microenvironments permissive to …

Targeting CCL2-CCR2 signaling pathway alleviates macrophage dysfunction in COPD via PI3K-AKT axis

Y Dong, Y Dong, C Zhu, L Yang, H Wang, J Li… - Cell Communication and …, 2024 - Springer
Background Chronic obstructive pulmonary disease (COPD) remains a leading cause of
morbidity and mortality worldwide, characterized by persistent respiratory symptoms and …

Monocyte-derived alveolar macrophages are key drivers of smoke-induced lung inflammation and tissue remodeling

CT Wohnhaas, K Baßler, CK Watson, Y Shen… - Frontiers in …, 2024 - frontiersin.org
Smoking is a leading risk factor of chronic obstructive pulmonary disease (COPD), that is
characterized by chronic lung inflammation, tissue remodeling and emphysema. Although …

Identification of drug candidates targeting monocyte reprogramming in people living with HIV

R Knoll, L Bonaguro, JC Dos Santos… - Frontiers in …, 2023 - frontiersin.org
Introduction People living with HIV (PLHIV) are characterized by functional reprogramming
of innate immune cells even after long-term antiretroviral therapy (ART). In order to assess …

The role of mitochondrial quality control in chronic obstructive pulmonary disease

YB Liu, JR Hong, N Jiang, L Jin, WJ Zhong… - Laboratory …, 2024 - Elsevier
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity, mortality, and
health care use worldwide with heterogeneous pathogenesis. Mitochondria, the …

Effectiveness of immunotherapy in non-small cell lung cancer patients with a diagnosis of COPD: is this a hidden prognosticator for survival and a risk factor for …

S Riondino, R Rosenfeld, V Formica, C Morelli, G Parisi… - Cancers, 2024 - mdpi.com
Simple Summary The interaction between the immune system, chronic obstructive
pulmonary disease (COPD), and non-small cell lung cancer (NSCLC) is complex and …

The role and mechanism of gut-lung axis mediated bidirectional communication in the occurrence and development of chronic obstructive pulmonary disease

X Song, X Dou, J Chang, X Zeng, Q Xu, C Xu - Gut Microbes, 2024 - Taylor & Francis
The current studies have shown that the occurrence and development of chronic obstructive
pulmonary disease (COPD) are closely related to the changes in gut health and its …

Immunological characteristics of bronchoalveolar lavage fluid and blood across connective tissue disease-associated interstitial lung diseases

A Hirano, A Sakashita, W Fujii, K Baßler… - Frontiers in …, 2024 - frontiersin.org
Interstitial lung disease (ILD) is a serious complication of connective tissue diseases (CTDs).
The heterogeneity of ILDs reflects differences in pathogenesis among diseases. This study …