Highly potent, but poorly water-soluble, drug candidates are common outcomes of
contemporary drug discovery programmes and present a number of challenges to drug …

Lipid-based delivery systems are finding increasing application in the oral delivery of poorly
water-soluble, lipophilic drugs. Whilst lipidic dose forms may improve oral bioavailability via …

Purpose The aim of this study was to update the compositions of biorelevant media to
represent the composition and physical chemical characteristics of the gastrointestinal fluids …

A revised classification system for oral drugs was developed using the biopharmaceutics
classification system (BCS) as a starting point. The revised system is designed to have a …

Drug absorption from the gastrointestinal (GI) tract is a highly complex process dependent
upon numerous factors including the physicochemical properties of the drug, characteristics …

Drug absorption, sufficient and reproducible bioavailability and/or pharmacokinetic profile in
humans are recognized today as one of the major challenges in oral delivery of new drug …

This review summarizes the current knowledge on anatomy and physiology of the human
gastrointestinal tract in comparison with that of common laboratory animals (dog, pig, rat and …

We need to look beyond our gut instincts to use information on “simple” intestinal
physiological parameters as they have been presented to us in the past. Here we present a …

Preformulation measurements are used to estimate the fraction absorbed in vivo for orally
administered compounds and thereby allow an early evaluation of the need for enabling …

Oral route is the most common route for the delivery of drugs because it is simple to
implement and improves patient compliance and quality of life. However, oral absorption is …