As a nontraditional T-cell subgroup, γδT cells have gained popularity in the field of
immunotherapy in recent years. They have extraordinary antitumor potential and prospects …

Butyrophilins (BTN) are relatives of the B7 family (eg, CD80, PD-L1). They fulfill a wide
range of functions including immunomodulation and bind to various receptors such as the γδ …

Crohn's disease (CD) is a chronic transmural inflammation of intestinal segments caused by
dysregulated interaction between microbiome and gut immune system. Here, we profile, via …

γδ T cells represent a substantial fraction of intestinal lymphocytes at homeostasis, but they
also constitute a major lymphocyte population infiltrating colorectal cancers (CRCs); …

The increasing implication of lymphocytes in general physiology and immune surveillance
outside of infection poses the question of how their antigen receptors might be involved …

Murine intraepithelial γδ T cells include distinct tissue-protective cells selected by epithelial
butyrophilin-like (BTNL) heteromers. To determine whether this biology is conserved in …

Intraepithelial lymphocytes (IELs), including αβ and γδ T cells (T-IELs), constantly survey
and play a critical role in maintaining the gastrointestinal epithelium. We show that cytotoxic …

The emergence of viruses with pandemic potential such as the SARS-CoV-2 coronavirus
causing COVID-19 poses a global health challenge. There is remarkable progress in …

Hepatocyte nuclear factor 4 α (HNF4A) is a highly conserved nuclear receptor that has been
associated with ulcerative colitis. In mice, HNF4A is indispensable for the maintenance of …

Rapid bench-to-bedside translation of basic immunology to cancer immunotherapy has
revolutionised the clinical practice of oncology over the last decade. Immune checkpoint …