Mitochondria are well known as organelles responsible for the maintenance of cellular
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …

The regulation of chronic inflammation has received considerable research attention in
recent years because of its contribution to the pathogenesis of chronic diseases such as …

Stochastic damage to cellular macromolecules and organelles is thought to be a driving
force behind aging and associated degenerative changes. However, stress response …

1.1. Discovery of Sirtuins The founding member of sirtuin is the yeast-silencing information
regulator 2 (SIR2) protein, one of four proteins (SIR1− 4) required for silencing the mating …

The IGF/mTOR pathway, which is modulated by nutrients, growth factors, energy status and
cellular stress regulates aging in various organisms. SIRT1 is a NAD+ dependent …

Sirtuins post-translationally modulate the function of many cellular proteins that undergo
reversible acetylation–deacetylation cycles, affecting physiological responses that have …

OBJECTIVE Macrophage recruitment to adipose tissue is a reproducible feature of obesity.
However, the events that result in chemokine production and macrophage recruitment to …

Abstract Background Sirtuins (SIRTs) are NAD+ dependent lysine deacetylases which are
conserved from bacteria to humans and have been associated with longevity and lifespan …

The sirtuin family has emerged as important regulators of diverse physiological and
pathological events, including life-span extension, neurodegeneration, age-related …

Scope Atherosclerosis is believed to be an independent predictor of cardiovascular
diseases. A growing body of evidence suggests that quercetin is a potent antioxidant and …