Molecular mechanisms and future implications of VEGF/VEGFR in cancer therapy
Angiogenesis, the sprouting of new blood vessels from existing vessels, is one of six known
mechanisms employed by solid tumors to recruit blood vessels necessary for their initiation …
mechanisms employed by solid tumors to recruit blood vessels necessary for their initiation …
VEGF in signaling and disease: beyond discovery and development
The discovery of vascular endothelial-derived growth factor (VEGF) has revolutionized our
understanding of vasculogenesis and angiogenesis during development and physiological …
understanding of vasculogenesis and angiogenesis during development and physiological …
Consensus guidelines for the use and interpretation of angiogenesis assays
The formation of new blood vessels, or angiogenesis, is a complex process that plays
important roles in growth and development, tissue and organ regeneration, as well as …
important roles in growth and development, tissue and organ regeneration, as well as …
Anti-angiogenesis for cancer revisited: Is there a role for combinations with immunotherapy?
RR Ramjiawan, AW Griffioen, DG Duda - Angiogenesis, 2017 - Springer
Angiogenesis is defined as the formation of new blood vessels from preexisting vessels and
has been characterized as an essential process for tumor cell proliferation and viability. This …
has been characterized as an essential process for tumor cell proliferation and viability. This …
Ten years of anti-vascular endothelial growth factor therapy
N Ferrara, AP Adamis - Nature reviews Drug discovery, 2016 - nature.com
The targeting of vascular endothelial growth factor A (VEGFA), a crucial regulator of both
normal and pathological angiogenesis, has revealed innovative therapeutic approaches in …
normal and pathological angiogenesis, has revealed innovative therapeutic approaches in …
Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia
RK Jain - Cancer cell, 2014 - cell.com
Ten antiangiogenic drugs targeting VEGF or its receptors are approved for cancer treatment.
However, these agents, intended to block tumors' blood supply, may cause hypoxia, which …
However, these agents, intended to block tumors' blood supply, may cause hypoxia, which …
VEGF targets the tumour cell
HL Goel, AM Mercurio - Nature Reviews Cancer, 2013 - nature.com
The function of vascular endothelial growth factor (VEGF) in cancer is not limited to
angiogenesis and vascular permeability. VEGF-mediated signalling occurs in tumour cells …
angiogenesis and vascular permeability. VEGF-mediated signalling occurs in tumour cells …
Normalizing tumor microenvironment to treat cancer: bench to bedside to biomarkers
RK Jain - Journal of Clinical Oncology, 2013 - ascopubs.org
For almost four decades, my work has focused on one challenge: improving the delivery and
efficacy of anticancer therapeutics. Working on the hypothesis that the abnormal tumor …
efficacy of anticancer therapeutics. Working on the hypothesis that the abnormal tumor …
PD-L1-directed PlGF/VEGF blockade synergizes with chemotherapy by targeting CD141+ cancer-associated fibroblasts in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) has a poor 5-year overall survival rate. Patients
with PDAC display limited benefits after undergoing chemotherapy or immunotherapy …
with PDAC display limited benefits after undergoing chemotherapy or immunotherapy …
Role of VEGFs/VEGFR-1 signaling and its inhibition in modulating tumor invasion: experimental evidence in different metastatic cancer models
C Ceci, MG Atzori, PM Lacal, G Graziani - International journal of …, 2020 - mdpi.com
The vascular endothelial growth factor (VEGF) family members, VEGF-A, placenta growth
factor (PlGF), and to a lesser extent VEGF-B, play an essential role in tumor-associated …
factor (PlGF), and to a lesser extent VEGF-B, play an essential role in tumor-associated …