Pancreatic stellate cells (PSCs) were identified in the early 1980s, but received much
attention after 1998 when the methods to isolate and culture them from murine and human …

Background Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant disease with a
very poor prognosis. To date patient outcomes have not improved principally due to the …

Simple Summary Cancer mortalities are growing at an alarming pace around the globe, a
fact related to challenges, such as side effects, selectivity, and resistance, accompanied by …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most common malignant tumors
with poor prognosis due to extremely high malignancy, low rate of eligibility for surgical …

Fibrosis is a process of tissue repair that results in the slow creation of scar tissue to replace
healthy tissue and can affect any tissue or organ. Its primary feature is the massive …

Pancreatic ductal adenocarcinoma is an aggressive and highly lethal disease frequently
characterized by a dense stromal or desmoplastic response. Accumulating evidence exists …

Pancreatic cancer is characterised by a prominent desmoplastic/stromal reaction. It is now
known that pancreatic stellate cells (PSCs) are the principal source of fibrosis in the stroma …

Immunotherapy efficacy depends on T cell trafficking to tumors and migrating to malignant
cells to kill them. One barrier to T cell homing is the tumor blood vessel wall, which inhibits T …

Pancreatic cancer is one of the most challenging adenocarcinomas due to its hostile
molecular behavior and complex tumor microenvironment. It has been recently postulated …

In chronic pancreatitis (CP), persistent activation of pancreatic stellate cells (PSC) converts
wound healing into a pathological process resulting in organ fibrosis. Here, we have …