Inflammation is a beneficial host reaction to tissue damage and has the essential primary
purpose of restoring tissue homeostasis. Inflammation plays a major role in containing and …

Although it is well established that platelet-activated receptor (PAF) and protease-activated
receptor 2 (PAR2) play a pivotal role in the pathophysiology of lung and airway inflammatory …

Eosinophils, leukocytes involved in allergic, inflammatory and immunoregulatory responses,
have a distinct capacity to rapidly secrete preformed granule‐stored proteins through …

Lipid mediators play an important role in modulating inflammatory responses. Platelet-
activating factor (PAF) is a potent proinflammatory phospholipid with eosinophil chemotactic …

The reperfusion of ischemic tissues may be associated with local and systemic inflammation
that prevents the full benefit of blood flow restoration. The present study aimed to confirm a …

Eosinophils are important inflammatory cells in allergic diseases. In the present study, we
have investigated the effects of CCL22 on the recruitment of eosinophils in vivo and in vitro …

Lung injury is a common finding and a frequent cause of death in cases of severe human
envenoming by scorpion sting. The present work investigated the effects of pretreatment with …

We describe the parasitological kinetics and histopathological and immunological
alterations in platelet-activating factor receptor-deficient (PAFR−/−) and wild-type mice after …

ABSTRACT PAF is a potent lipid mediator involved in several manifestations of acute
inflammation, including leukocyte influx, leukocyte interaction with endothelium, and …

The generation of an inflammatory response driven by Trypanosoma cruzi or its subproducts
appears to be essential for tissue injury and disease pathogenesis. However, this …