Abstract Calcium (Ca2+) signalling is of paramount importance to immunity. Regulated
increases in cytosolic and organellar Ca2+ concentrations in lymphocytes control complex …

Lysosomes are acidic compartments filled with more than 60 different types of hydrolases.
They mediate the degradation of extracellular particles from endocytosis and of intracellular …

Lysosomes have traditionally been viewed as degradative organelles, although a growing
body of evidence suggests that they can function as Ca 2+ stores. Here we examined the …

Natural killer (NK) cell‐mediated cytotoxicity is governed by the formation of a lytic immune
synapse in discrete regulated steps, which give rise to an extensive array of cellular …

Inhibitory signaling during natural killer (NK) cell education translates into increased
responsiveness to activation; however, the intracellular mechanism for functional tuning by …

Two-pore channels (TPCs) are endolysosomal ion channels implicated in Ca2+ signalling
from acidic organelles. The relevance of these ubiquitous proteins for human disease …

The second messenger NAADP triggers Ca2+ release from endo‐lysosomes. Although two‐
pore channels (TPC s) have been proposed to be regulated by NAADP, recent studies have …

Vascular endothelial growth factor (VEGF) and its receptors VEGFR1/VEGFR2 play major
roles in controlling angiogenesis, including vascularization of solid tumors. Here we …

Cytotoxic T lymphocytes (CTLs) kill virus-infected and tumour cells with remarkable
specificity. Upon recognition, CTLs form a cytolytic immune synapse with their target cell …

Two-pore channels (TPCs) are evolutionarily important members of the voltage-gated ion
channel superfamily. TPCs localize to acidic Ca2+ stores within the endolysosomal system …