In recent years, our understanding of protein structure and function has advanced rapidly,
providing a mechanistic understanding of a wide variety of biological processes. As an …

Complement fragment (C) 5a is a 74 residue pro‐inflammatory polypeptide produced during
activation of the complement cascade of serum proteins in response to foreign surfaces such …

▪ Abstract De novo protein design has recently emerged as an attractive approach for
studying the structure and function of proteins. This approach critically tests our …

The folded 3D structures of peptides and proteins provide excellent starting points for the
design of synthetic molecules that mimic key epitopes (or surface patches) involved in …

Serine, threonine-derived (4 S)-oxazolidine-4-carboxylic acid, and cysteine-derived (4 R)-
thiazolidinecarboxylic acid, denoted pseudo-proline (Xaa [ΨR1, R2pro]), serve as structure …

Ligand binding and concomitant changes in receptor structure provide the means to target
signal transduction pathways. With appropriate refinement of the ligand's interaction with the …

Cyclization and selected backbone N-methylations are found to be often necessary but not
sufficient conditions for peptidic drugs to have a good bioavailability. Thus, the design of …

Analyses of high resolution crystal structures have shown that antibody hypervariable loops
L1, L2, and L3 from the light chain, as well as H1 and H2 from the heavy chain, can be …

De novo designed peptides, capable of undergoing a thermally triggered β-strand-swapped
self-assembly event leading to hydrogel formation were prepared. Strand-swapping peptide …

The effort to modulate challenging protein targets has stimulated interest in ligands that are
larger and more complex than typical small-molecule drugs. While combinatorial techniques …