Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis that presents with rapidly
developing, painful skin ulcers hallmarked by undermined borders and peripheral erythema …

Psoriasis is a chronic, inflammatory multisystem disease that affects up to 3.2% of the US
population. This guideline addresses important clinical questions that arise in psoriasis …

Methotrexate has been used in treatment of rheumatoid arthritis (RA) since the 1980s and to
this day is often the first line medication for RA treatment. In this review, we examine multiple …

Antibody‐based cancer therapy, one of the most significant therapeutic strategies, has
achieved considerable success and progress over the past decades. Nevertheless …

Although the introduction of tumor necrosis factor (TNF) inhibitors represented a significant
advance in the treatment of rheumatoid arthritis (RA), traditional anti-TNFα antibodies are …

Fully human monoclonal antibodies (mAbs) are a promising and rapidly growing category of
targeted therapeutic agents. The first such agents were developed during the 1980s, but …

Context Short-term data on the immunogenicity of monoclonal antibodies showed
associations between the development of antidrug antibodies and diminished serum drug …

The development of therapeutic antibodies has evolved over the past decade into a
mainstay of therapeutic options for patients with autoimmune and inflammatory diseases …

Abstract Background and Aims: The efficacy of azathioprine for Crohn's disease under
adalimumab treatment remains obscure. Methods: In an open-labelled prospective study …

During the past 30 years, elucidation of the pathogenesis of rheumatoid arthritis, Crohn's
disease, psoriasis, psoriatic arthritis and ankylosing spondylitis at the cellular and molecular …