Post-translational modifications (PTMs) on tau have long been recognized as affecting
protein function and contributing to neurodegeneration. The explosion of information on …

Programed cell death plays a key role in promoting human development and maintaining
homeostasis. Ferroptosis is a recently identified pattern of programmed cell death that is …

At the present time, no viable treatment exists for cognitive and olfactory deficits in Down
syndrome (DS). We show in a DS model (Ts65Dn mice) that these progressive …

JCI - Caffeine intake exerts dual genome-wide effects on hippocampal metabolism and
learning-dependent transcription Go to JCI Insight About Editors Consulting Editors For authors …

Organisms respond to mitochondrial stress by activating multiple defense pathways,
including the mitochondrial unfolded protein response (UPRmt). However, how UPRmt …

Microglia play a critical role in maintaining neural function. While microglial activity follows a
circadian rhythm, it is not clear how this intrinsic clock relates to their function, especially in …

Background The trans-neuronal propagation of tau has been implicated in the progression
of tau-mediated neurodegeneration. There is critical knowledge gap in understanding how …

After a spinal cord injury, axons fail to regenerate in the adult mammalian central nervous
system, leading to permanent deficits in sensory and motor functions. Increasing neuronal …

Alzheimer's disease (AD) is the most common neurodegenerative disease, which severely
threatens the health of the elderly and causes significant economic and social burdens. The …

The interruption of spinal circuitry following spinal cord injury (SCI) disrupts neural activity
and is followed by a failure to mount an effective regenerative response resulting in …