Platinum‐based chemotherapy is often used as a first‐line treatment for patient with breast cancer. Platinum agents bind to DNA, forming adducts that contain intra and inter‐strand …
A Grenda, J Błach, M Szczyrek, P Krawczyk… - Cancer …, 2020 - Wiley Online Library
Abstract Background Topoisomerase 2‐alpha (TOP2A) is an enzyme that controls topologic changes in DNA during transcription and replication. ERCC1 is an enzyme that takes part in …
Purpose: Cancer is the leading cause of death in economically developed countries and the second leading cause of death in developing countries. The relationship between genetic …
X Liu, Z Chen, X Zhao, M Huang, C Wang… - …, 2015 - Taylor & Francis
Aim: The present study analyzed Type 2 diabetes mellitus (T2D)-related gene polymorphisms and their impacts on chemotherapeutic response and survival in patients …
SC Ma, Y Zhao, T Zhang, XL Ling… - OncoTargets and …, 2015 - Taylor & Francis
Purpose The relationship between the excision repair cross-complementing 1 (ERCC1) rs11615 polymorphism (C/T) and responses to oxaliplatin-based chemotherapy for gastric …
R Hou, Y Liu, YE Feng, L Sun, Z Shu, J Zhao, S Yang - Gene, 2014 - Elsevier
We investigated the association between polymorphisms in excision repair cross- complementation group 1 (ERCC1)(rs3212986, rs2298881 and rs11615) and xeroderma …
H Zhang, Y Li, S Guo, Y Wang, H Wang… - American journal of …, 2020 - ncbi.nlm.nih.gov
Purpose: The 5-year survival rate of patients with lung cancer in China is< 20%, and predicting their prognosis is difficult. Here, we investigated the association between two …
YK Wang, SN Wang, YY Li, GP Wang, T Yun… - Cancer …, 2018 - content.iospress.com
OBJECTIVE: This study aims to investigate the significance of combined detection of HER2 gene amplification and chemosensitivity in gastric cancer. METHODS …
H Gao, RC Ge, HY Liu, Y Wang, S Yan - Genet Mol Res, 2014 - funpecrp.com.br
We conducted a cohort study to investigate the role of 3 single-nucleotide polymorphisms of the excision repair crosscomplementation group 1 (ERCC1) gene on the response to …