Genetics and precision genomics approaches to pulmonary hypertension

ED Austin, MA Aldred, M Alotaibi… - European …, 2024 - publications.ersnet.org
Considerable progress has been made in the genomics of pulmonary arterial hypertension
(PAH) since the 6th World Symposium on Pulmonary Hypertension, with the identification of …

Polyglutamine disorders: Pathogenesis and potential drug interventions

S Tandon, P Aggarwal, S Sarkar - Life Sciences, 2024 - Elsevier
Polyglutamine/poly (Q) diseases are a group nine hereditary neurodegenerative disorders
caused due to abnormally expanded stretches of CAG trinucleotide in functionally distinct …

Functional implications of protein arginine methyltransferases (PRMTs) in neurodegenerative diseases

E Angelopoulou, ES Pyrgelis, C Ahire, P Suman… - Biology, 2023 - mdpi.com
Simple Summary In search of common pathophysiological events among
neurodegenerative diseases, arginine methylation of proteins has been revealed as a …

The impact of interleukin-6 (IL-6) and mesenchymal stem cell-derived IL-6 on neurological conditions

I Kerkis, ÁP Silva, RP Araldi - Frontiers in Immunology, 2024 - frontiersin.org
Interleukin-6 (IL-6) is a versatile cytokine crucial for immune response modulation,
inflammation regulation, and various physiological processes in the body. Its wide-ranging …

The formation and function of the VTA dopamine system

G Hou, M Hao, J Duan, MH Han - International Journal of Molecular …, 2024 - mdpi.com
The midbrain dopamine system is a sophisticated hub that integrates diverse inputs to
control multiple physiological functions, including locomotion, motivation, cognition, reward …

[HTML][HTML] Large animal models for Huntington's disease research

B Han, W Liang, XJ Li, S Li, S Yan, Z Tu - Zoological Research, 2024 - ncbi.nlm.nih.gov
Huntington's disease (HD) is a hereditary neurodegenerative disorder for which there is
currently no effective treatment available. Consequently, the development of appropriate …

Computational Assessment of the Phytochemicals of Panax ginseng CA Meyer Against Dopamine Receptor D1 for Early Huntington's Disease Prophylactics

JA Subin, RLS Shrestha - Cell Biochemistry and Biophysics, 2024 - Springer
A herb, Panax ginseng CA Meyer has been used traditionally for the treatment of various
diseases. In this work, its chemical components have been explored by computational …

Single nuclei RNA-seq reveals a medium spiny neuron glutamate excitotoxicity signature prior to the onset of neuronal death in an ovine Huntington's disease model

A Jiang, L You, RR Handley, V Hawkins… - Human Molecular …, 2024 - academic.oup.com
Huntington's disease (HD) is a neurodegenerative genetic disorder caused by an expansion
in the CAG repeat tract of the huntingtin (HTT) gene resulting in behavioural, cognitive, and …

[HTML][HTML] Present and future use of exosomes containing proteins and RNAs in neurodegenerative diseases for synaptic function regulation: A comprehensive review

Z Liu, L Cheng, W Cao, C Shen, Y Qiu, C Li… - International Journal of …, 2024 - Elsevier
Neurodegenerative diseases (NDDs) are increasingly prevalent with global aging,
demanding effective treatments. Exosomes, which contain biological macromolecules such …

The role of Nα‐terminal acetylation in protein conformation

S Calis, K Gevaert - The FEBS Journal, 2024 - Wiley Online Library
Especially in higher eukaryotes, the N termini of proteins are subject to enzymatic
modifications, with the acetylation of the alpha‐amino group of nascent polypeptides being a …