Secretory IgA (SIgA) plays an important role in the protection and homeostatic regulation of
intestinal, respiratory, and urogenital mucosal epithelia separating the outside environment …

Studies of the relationship between the microbiome and the development and function of the
immune system are demonstrating novel concepts that could significantly alter the way we …

Cholera toxin (CT) is a potent adjuvant for inducing mucosal immune responses. However,
the mechanism by which CT induces adjuvant activity remains unclear. Here we show that …

The skin of vertebrates is the outermost organ of the body and serves as the first line of
defense against external aggressions. In contrast to mammalian skin, that of teleost fish …

Vibrio cholerae is a prototypical noninvasive mucosal pathogen, yet infection generates long-
lasting protection against subsequent disease. Vibriocidal antibody responses are an …

Vibrio cholerae is a noninvasive pathogen that colonizes the small intestine and produces
cholera toxin, causing severe secretory diarrhea. Cholera results in long lasting immunity …

Sporotrichosis associated with zoonotic transmission remains a relevant public health
problem in Rio de Janeiro, Brazil, affecting a large at-risk population, which includes HIV …

Background Mucosal Associated Invariant T (MAIT) cells are innate-like T cells found in
abundance in the intestinal mucosa, and are thought to play a role in bridging the innate …

The development of new approaches to cholera control relies on an accurate understanding
of cholera epidemiology. However, most information on cholera incidence lacks laboratory …

Introduction The public health burden caused by pathogenic Gram-negative bacteria is
increasingly prominent due to antimicrobial resistance. The surface carbohydrates are …