Dendritic cells (DCs) initiate and shape both the innate and adaptive immune responses.
Accordingly, recent evidence from clinical studies and experimental models implicates DCs …

Mononuclear phagocytes (MPs) relevant to atherosclerosis include monocytes,
macrophages, and dendritic cells. A decade ago, studies on macrophage behavior in …

We examine the features, origin, turnover, and gene expression of pancreatic macrophages
under steady state. The data distinguish macrophages within distinct intrapancreatic …

Type 1 diabetes (T1D) results from a complex interplay between genetic susceptibility and
environmental factors that have been implicated in the pathogenesis of disease both as …

Islet amyloid polypeptide (IAPP) aggregates to form amyloid fibrils in patients with type 2
diabetes and acts as a potent stimulus for interleukin (IL)-1β secretion by bone marrow …

Pancreatic-islet inflammation contributes to the failure of β cell insulin secretion during
obesity and type 2 diabetes. However, little is known about the nature and function of …

Inflammation is a highly dynamic process with immune cells that continuously interact with
each other and parenchymal components as they migrate through tissue. The dynamic …

Autoimmune diabetes is characterized by inflammatory infiltration; however, the initiating
events are poorly understood. We found that the islets of Langerhans in young nonobese …

In addition to the genetic framework, there are two other critical requirements for the
development of tissue-specific autoimmune disease. First, autoreactive T cells need to …

In both type 1 and type 2 diabetes, pancreatic islet dysfunction results in part from cytokine-
mediated inflammation. The ubiquitous eukaryotic translation initiation factor 5A (eIF5A) …