New drugs against malaria are greatly needed. Many approaches to antimalarial drug
discovery are available. These approaches must take into account specific concerns, in …

This review is focused on recent advances and new aspects in the field of molecular docking
and scoring, and it covers multiple applications and case studies. Basic requirements and …

A number of cysteine proteases of malaria parasites have been described and many more
are suggested by analysis of the Plasmodium falciparum genome sequence. The best …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by dementia,
memory impairment, cognitive dysfunction, and speech impairment. The utility of cholinergic …

Malaria, particularly that one caused by Plasmodium falciparum, remains a serious health
problem in Africa, South America, and many parts of Asia where it afflicts about 500 million …

Strategies for the production of substituted isoquinoline libraries were developed and
explored. Routes involving microwave-assisted variants of the Bischler− Napieralski or …

Rhodesain, a cathepsin L-like cysteine protease of T. brucei rhodesiense, is considered a
potential target for the treatment of human African trypanosomiasis. Recent findings have …

Both the lack of a credible malaria vaccine and the emergence and spread of parasites
resistant to most of the clinically used antimalarial drugs and drug combination have …

There is a high demand for new drugs against malaria, which takes millions of lives
annually. The abuse of classical antimalarials from the late 1940's to the early 1980's has …

Lamellarin D, a marine natural product, acts as a potent inhibitor of DNA topoisomerase I
(Topo I). To modify its physicochemical property and biological activity, a series of mono-and …