Islet amyloid polypeptide (IAPP, or amylin) is one of the major secretory products of β-cells of
the pancreatic islets of Langerhans. It is a regulatory peptide with putative function both …

The hormone islet amyloid polypeptide (IAPP, or amylin) plays a role in glucose
homeostasis but aggregates to form islet amyloid in type‐2 diabetes. Islet amyloid formation …

The 37-residue amylin peptide, also known as islet amyloid polypeptide, forms fibrils that are
the main peptide or protein component of amyloid that develops in the pancreas of type 2 …

In general, proteins can only execute their various biological functions when they are
appropriately folded. Their amino acid sequence encodes the relevant information required …

Amyloid formation by the neuropancreatic hormone, islet amyloid polypeptide (IAPP or
amylin), one of the most amyloidogenic sequences known, leads to islet amyloidosis in type …

There is considerable interest in uncovering the pathway of amyloid formation because the
toxic properties of amyloid likely stems from prefibril intermediates and not the fully formed …

Islet amyloid polypeptide (IAPP) forms cytotoxic oligomers and amyloid fibrils in islets in type
2 diabetes (T2DM). The causal factors for amyloid formation are largely unknown …

Protein function and flexibility is directly related to the native distribution of its structural
elements and any alteration in protein architecture leads to several abnormalities and …

The tetrameric thyroxine transport protein transthyretin (TTR) forms amyloid fibrils upon
dissociation and monomer unfolding. The aggregation of transthyretin has been reported as …

Oligomerization of human islet amyloid polypeptide (IAPP) has been increasingly
considered a pathogenic process in type II diabetes. Here structural features of the IAPP …