Autophagy is a process that targets various intracellular elements for degradation.
Autophagy can be non-selective—associated with the indiscriminate engulfment of cytosolic …

Mitochondria are traditionally known as the powerhouse of the cell, but their functions
extend far beyond energy production. They are vital in cellular and organismal pathways …

Mitochondrial damage causes mitochondrial DNA (mtDNA) release to activate the type I
interferon (IFN-I) response via the cGAS-STING pathway. mtDNA-induced inflammation …

Microglia continuously survey the brain parenchyma and actively shift status following
stimulation. These processes demand a unique bioenergetic programme; however, little is …

Macrophage‐stimulator of interferon genes (STING) signaling mediated sterile inflammation
has been implicated in various age‐related diseases. However, whether and how …

Selective autophagy specifically eliminates damaged or superfluous organelles, maintaining
cellular health. In this process, a double membrane structure termed an autophagosome …

Mitophagy is a fundamental quality control mechanism of mitochondria. Its regulatory
mechanisms and pathological implications remain poorly understood. Here, via a …

Necroptosis is the major cause of death in alveolar epithelial cells (AECs) during acute lung
injury (ALI). Here, we report a previously unrecognized mechanism for necroptosis. We …

Despite the emergence of mitochondria as key regulators of innate immunity, the
mechanisms underlying the generation and release of immunostimulatory alarmins by …

Obesity is one of the prominent global health issues, contributing to the growing prevalence
of insulin resistance and type 2 diabetes. Chronic inflammation in adipose tissue is …