Actin dynamics in cell motility, division, and phagocytosis is regulated by complex factors
with multiple feedback loops, often leading to emergent dynamic patterns in the form of …

Chemotaxis, or directed migration of cells along a chemical gradient, is a highly coordinated
process that involves gradient sensing, motility, and polarity. Most of our understanding of …

During cell migration and polarization, numerous signal transduction and cytoskeletal
components self-organize to generate localized protrusions. Although biochemical and …

Although directed migration of eukaryotic cells may have evolved to escape nutrient
depletion, it has been adopted for an extensive range of physiological events during …

Migration of neural progenitors in the complex tissue environment of the central nervous
system is not well understood. Progress in this area has the potential to drive breakthroughs …

Cell polarization is a key step in the migration, development, and organization of eukaryotic
cells, both at the single cell and multicellular level. Research on the mechanisms that give …

Pairs of endothelial cells on adhesive micropatterns rotate persistently, but pairs of
fibroblasts do not; coherent rotation is present in normal mammary acini and kidney cells but …

The diverse migratory modes displayed by different cell types are generally believed to be
idiosyncratic. Here we show that the migratory behaviour of Dictyostelium was switched from …

Ras has been extensively studied as a promoter of cell proliferation, whereas few studies
have explored its role in migration. To investigate the direct and immediate effects of Ras …

Cell migration is hypothesized to involve a cycle of behaviours beginning with leading edge
extension. However, recent evidence suggests that the leading edge may be dispensable …