Renal tubular epithelial cells (TECs) play a key role in kidney fibrosis by mediating cycle
arrest at G2/M. However, the key HDAC isoforms and the underlying mechanism that are …

Lipid metabolism, especially fatty acid oxidation (FAO) dysfunction, is a major driver of renal
fibrosis; however, the detailed regulatory mechanisms involved remain unclear. In this study …

In the last few decades, the prevalence of diabetes mellitus (DM) has increased rapidly.
Diabetic kidney disease (DKD) is the major cause of end-stage renal disease (ESRD) …

Precise regulation of cell cycle is essential for tissue homeostasis and development, while
cell cycle dysregulation is associated with many human diseases including renal fibrosis, a …

A series of novel menthone derivatives bearing pyrimidine and urea moieties was designed
and synthesized to explore more potent natural product-derived antitumor agents. The …

Suppression of Allograft Fibrosis by Regulation of Mammalian Target of Rapamycin-Related
Protein Expression in Kidney-Transplanted Recipients Treated with Everolimus and …

Abstract Bcl‐2 associated athanogene 5 (Bag5) is a novel endoplasmic reticulum (ER)
regulator. However, its role in catecholamine‐induced endothelial cells damage has not …

Our previous study demonstrated that the mammalian target of rapamycin complex 1
(mTORC1) pathway is activated in peritoneal fibrosis under high glucose condition. This …

慢性肾脏病(CKD) 是威胁人类公共健康的重大疾病之一, 肾间质纤维化是各种CKD
进展至终末期肾病的共同病理表现. 然而肾间质纤维化的病理机制还有待阐明 …

Chronic kidney disease is one of the major diseases threatening public health. Renal
interstitial fibrosis (RIF) is a common pathological manifestation of various chronic kidney …