The molecular pathways that govern human disease consist of molecular circuits that
coalesce into complex, overlapping networks. These network pathways are presumably …

One of the early success stories of computational systems biology was the work done on cell-
cycle regulation. The earliest mathematical descriptions of cell-cycle control evolved into …

After DNA damage, cells activate p53, a tumor suppressor gene, and select a cell fate (eg,
DNA repair, cell cycle arrest, or apoptosis). Recently, a p53 oscillatory behavior was …

Dynamical modelling is at the core of the systems biology paradigm. However, the
development of comprehensive quantitative models is complicated by the daunting …

Background Parametric sensitivity analysis (PSA) has become one of the most commonly
used tools in computational systems biology, in which the sensitivity coefficients are used to …

Background The cell cycle is a complex process that allows eukaryotic cells to replicate
chromosomal DNA and partition it into two daughter cells. A relevant regulatory step is in the …

The ability of a cell to conserve and maintain its native DNA sequence is fundamental for the
survival and normal functioning of the whole organism and protection from cancer …

Not many models of mammalian cell cycle system exist due to its complexity. Some models
are too complex and hard to understand, while some others are too simple and not …

Many complex kinetic models in the field of biochemical reactions contain a large number of
species and reactions. These models often require a huge array of computational tools to …

We investigate the robustness and the behaviours of the critical proteins under parameter
perturbations of G1/S checkpoint pathways with different levels of DNA-damage, based on a …