Most of science involves making observations, forming hypotheses, and testing those
hypotheses, to form valid conclusions. However, a distinct, longstanding, and very …

An opioid epidemic is spreading in North America with millions of opioid overdoses
annually. Opioid drugs, like fentanyl, target the mu opioid receptor system and induce …

A recently reported behavioral screen in larval zebrafish for phenocopiers of known
anesthetics and associated drugs yielded an isoflavone. Related isoflavones have also …

Benzodiazepines (BZDs) produce versatile pharmacological actions through positive
modulation of GABAA receptors (GABAARs). A previous study has demonstrated that high …

Background and Purpose In addition to binding to the classical high‐affinity extracellular
benzodiazepine binding site of the GABAA receptor, some benzodiazepines occupy …

Objective: To observe the effect of etomidate on spatial learning and memory and neuronal
apoptosis in rats of different ages. Methods: The rats of different ages were divided into 3 …

Increasing ambient pressure has been suggested to reverse general anaesthesia and
provides support for the 'lipid theory'. Anaesthetic dissolution into cell membranes is said to …

As a γ-aminobutyric acid A receptor (GABA AR) inhibitor, etomidate fulfills several
characteristics of an ideal anesthetic agent, such as rapid onset with rapid clearance and …

Background and Aims: Diazepam is accepted as a safer drug to medicate in many serious
cases, acting as an anticonvulsant, an anxiolytic and a treatment for many types of …

Opioids are strong pain relievers that also present the severe side effect of respiratory
depression which can be lethal with overdose. Opioids mechanisms of inhibition are not well …