Recombination promotes genomic integrity among cells and tissues through double-strand
break repair, and is critical for gamete formation and fertility through a strict regulation of the …

Cancer cells have recently been shown to activate hundreds of normally silent tissue-
restricted genes, including a specific subset associated with cancer progression and poor …

Cancer cells have many abnormal characteristics enabling tumors to grow, spread, and
avoid immunologic and therapeutic destruction. Central to this is the innate ability of …

Abnormal gene expression in cancer represents an under-explored source of cancer
markers and therapeutic targets. In order to identify gene expression signatures associated …

Background Large-scale genetic and epigenetic deregulations enable cancer cells to
ectopically activate tissue-specific expression programmes. A specifically designed strategy …

In Saudi Arabia, colon cancer (CC) is the most prevalent cancer in men and the third most
common cancer in women. Rather than being detected through screening programs, most …

Conventional non-surgical therapeutic regimens against osteosarcoma are subject to
chemoresistance and tumor relapse, and immunotherapy may be promising for this tumor …

Lung cancer is the leading cause of cancer deaths in both genders worldwide, with an
incidence only second to prostate cancer in men and breast cancer in women. The lethality …

Sex affects the risk, treatment responses and outcome of many types of cancers. The
mechanism of gender disparity in development of hepatocellular carcinoma (HCC) remains …

Cancer testis antigens (CTAs) are widely expressed in tumor tissues, circulating tumor cells
(CTCs) and in cancer derived exosomes that are frequently engulfed by lymphoid cells. To …