The advanced, metastatic differentiated thyroid cancers (DTCs) have a poor prognosis
mainly owing to radioactive iodine (RAI) refractoriness caused by decreased expression of …

Radioiodine-refractory differentiated thyroid cancer (RAIR-DTC) is difficult to treat with
radioactive iodine because of the absence of the sodium iodide transporter in the basement …

The management of radioiodine refractory thyroid cancers (RAIR TC) is challenging for the
clinician. Tyrosine kinase inhibitors classically prescribed in this setting can fail due to …

The Notch family is a highly conserved gene group that regulates cell‐cell interaction,
embryogenesis, and tissue commitment. This review article focuses on the third Notch family …

Epithelial-mesenchymal transition (EMT) is implicated in the metastasis of human prostate
cancer (PCa). Notch signaling has been established as a regulator of EMT. Notch-4 has …

Thyroid cancer is the most common malignancy of the endocrine system with a steadily
rising incidence. The term “thyroid cancer” encompasses a spectrum of subtypes, namely …

Arteriogenesis supplies oxygen and nutrients in the tumor microenvironment (TME), which
may play an important role in tumor growth and metastasis. Pancreatic neuroendocrine …

Notch signaling, renowned for its role in regulating cell fate, organ development, and tissue
homeostasis across metazoans, is highly conserved throughout evolution. The Notch …

Neuroendocrine neoplasms (NENs) comprise a heterogeneous group of rare malignancies,
mainly originating from hormone-secreting cells, which are widespread in human tissues …

Patients diagnosed with radioiodine refractory thyroid cancer (RAIR‐TC) are not amenable
to novel 131I therapy due to the reduced expression of sodium iodide symporter (Na+/I …