The discovery of vascular endothelial-derived growth factor (VEGF) has revolutionized our
understanding of vasculogenesis and angiogenesis during development and physiological …

Oxidative stress-induced damage to the retinal pigment epithelium (RPE) is considered to
be a key factor in age-related macular degeneration (AMD) pathology. RPE cells are …

Reticular pseudodrusen (RPD), or subretinal drusenoid deposits (SDD), refer to distinct
lesions that occur in the subretinal space. Over the past three decades, their presence in …

Cholesterol homeostasis is essential in normal physiology of all cells. One of several
proteins involved in cholesterol homeostasis is the ATP-binding cassette transporter A1 …

Age-related diseases, including age-related macular degeneration (AMD), are of growing
importance in a world where population ageing has become a dominant global trend …

Age-related macular degeneration is a primary cause of blindness in the older adult
population. Past decades of research in the pathophysiology of the disease have resulted in …

Introduction Intravitreal anti-vascular endothelial growth factor (VEGF) injections for
exudative age-related macular degeneration (eAMD) are effective and safe but require …

Purpose: To clarify the role of subretinal drusenoid deposits (SDD; pseudodrusen) in the
progression of age-related macular degeneration through high-resolution histology …

Age-related macular degeneration (AMD) is a progressive disease of the retinal pigment
epithelium (RPE) and the retina leading to loss of central vision. Polymorphisms in genes …

Roundabout (ROBO) 1 and 2 are transmembrane receptors that bind secreted SLIT ligands
through their extracellular domains (ECDs) and signal through their cytoplasmic domains to …