Porcine vagina ex vivo as a model for studying permeability and pathogenesis in mucosa

CA Squier, MJ Mantz, PM Schlievert… - Journal of pharmaceutical …, 2008 - Elsevier
The vaginal mucosa is commonly exposed to a variety of topical agents, including chemical
contraceptives, drugs for the treatment of specific pathological conditions, and pathogenic …

Studies and methodologies on vaginal drug permeation

RM Machado, A Palmeira-de-Oliveira, C Gaspar… - Advanced drug delivery …, 2015 - Elsevier
The vagina stands as an important alternative to the oral route for those systemic drugs that
are poorly absorbed orally or are rapidly metabolized by the liver. Drug permeation through …

Intraoral drug delivery: Highly thiolated κ-carrageenan as mucoadhesive excipient

G Kali, A Fürst, NA Efiana, A Dizdarević… - Pharmaceutics, 2023 - mdpi.com
Aim: This study aims to design a novel thiolated κ-carrageenan (κ-CA-SH) and evaluate its
potential as an excipient for the design of mucoadhesive drug delivery systems. Methods …

Cell-penetrating self-nanoemulsifying drug delivery systems (SNEDDS) for oral gene delivery

A Mahmood, F Prüfert, NA Efiana… - Expert opinion on …, 2016 - Taylor & Francis
Objective: The aim of study was to investigate whether cell-penetrating peptides could
amplify cellular uptake of plasmid DNA (pDNA) loaded self-nanoemulsifying drug delivery …

Types and evaluation of in vitro penetration models for buccal mucosal delivery

S Wang, A Zuo, J Guo - Journal of Drug Delivery Science and Technology, 2021 - Elsevier
Oral buccal mucosal delivery has the advantage of avoiding gastrointestinal drug
degradation, reducing hepatic firstpass effects, and improving patient compliance. In recent …

Glycobiology of the ocular surface: mucins and lectins

P Argüeso - Japanese journal of ophthalmology, 2013 - Springer
Glycosylation is an important and common form of posttranscriptional modification of
proteins in cells. During the last decade, a vast array of biological functions has been …

Comparison of ATR–FTIR spectra of porcine vaginal and buccal mucosa with ear skin and penetration analysis of drug and vehicle components into pig ear

JC Schwarz, E Pagitsch, C Valenta - European Journal of Pharmaceutical …, 2013 - Elsevier
In the present study, porcine buccal and vaginal mucosae were successfully characterised
by ATR–FTIR for the first time and compared to porcine ear skin. By analysing typical bands …

Evaluation of lectin nanoscaffold based in-situ gel against vulvovaginal candidiasis causing Candida biofilms using a novel ex-vivo model

J Senthilganesh, L Deepak, R Durai… - Journal of Drug Delivery …, 2022 - Elsevier
Vulvovaginal Candidiasis (VVC) remains a global issue for women of the reproductive age
group. It is mainly caused by Candida albicans and in some cases includes a co-infection …

Porcine vaginal mucosa as an in vitro permeability model for human vaginal mucosa

AD van Eyk, P van der Bijl - International journal of pharmaceutics, 2005 - Elsevier
The availability of human tissue for experimental purposes is often problematical and use is
thus made of animal tissue as models of the human tissue. In this study, porcine vaginal …

[PDF][PDF] Vaginal drug delivery

J das Neves, MH Amaral, MF Bahia - … handbook: production and …, 2008 - academia.edu
5.12. 2 The Human Vagina 5.12. 2.1 Anatomy 5.12. 2.2 Histology 5.12. 2.3 Physiology 5.12.
2.4 Childhood, Pregnancy, and Menopause 5.12. 3 General Features of Vaginal Drug …