Breast cancer is the most commonly diagnosed cancer in women. Metastasis is the primary
cause of mortality for breast cancer patients. Multiple mechanisms underlie breast cancer …

It is well established that multifactorial drug resistance hinders successful cancer treatment.
Tumor cell interactions with the tumor microenvironment (TME) are crucial in epithelial …

Abstract The IL-6/JAK/STAT3 pathway is aberrantly hyperactivated in many types of cancer,
and such hyperactivation is generally associated with a poor clinical prognosis. In the …

The CRISPR/Cas9 system is an RNA-based adaptive immune system in bacteria and
archaea. Various studies have shown that it is possible to target a wide range of human …

Macrophages are the most abundant and one of the most critical cells of tumor immunity.
They provide a bridge between innate and adaptive immunity through releasing cytokines …

Malignant tumors are highly heterogeneous and likely contain a subset of cancer cells
termed cancer stem cells (CSCs). CSCs exist in a dynamic equilibrium with their …

Inflammation mediated by activation of JAK/STAT signaling is a major cause of
chemotherapy resistance in cancer. We studied the impact of selectively blocking the IL6 …

Simple Summary Many signaling pathways are overactive in breast cancer, and among
them is the STAT3 signaling pathway. STAT3 is activated by secreted factors within the …

Background The role of tumor necrosis factor alpha (TNF-α) in targeted therapy for
hepatocellular carcinoma (HCC) remains largely unknown. The current study aimed to …

Simple Summary Breast cancer (BC) is not a single disease, but a group of different tumors,
and altered HER2 expression defines a particularly aggressive subtype. Although HER2 …