Gene regulation through DNA methylation is a well described phenomenon that has a
prominent role in physiological and pathological cell-states. This epigenetic modification is …

Simple Summary Bone marrow disorders such as leukemia and myelodysplastic syndromes
are characterized by abnormal healthy blood cells production and function. Uncontrolled …

Myeloid neoplasms are clonal hematopoietic stem cell disorders driven by the sequential
acquisition of recurrent genetic lesions. Truncating mutations in the chromatin remodeler …

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) constitutes a rare and aggressive
malignancy originating from plasmacytoid dendritic cells (pDCs) with a primarily cutaneous …

Chronic myelomonocytic leukemia (CMML) is an aggressive myeloid neoplasm of older
individuals characterized by persistent monocytosis. Somatic mutations in CMML are …

Molecular clocks that record cell ancestry mutate too slowly to measure the short-timescale
dynamics of cell renewal in adult tissues. Here, we show that fluctuating DNA methylation …

Chronic myelomonocytic leukemia (CMML) is a severe myeloid malignancy affecting the
elderly, for which therapeutic options are limited. DNA hypomethylating agents (HMAs) …

Tumor classifiers based on molecular patterns promise to define and reliably classify tumor
entities. The high tissue-and cell type-specificity of DNA methylation, as well as its high …

Introduction Chronic myelomonocytic leukemia (CMML) is a clonal myeloid neoplasm,
denoted by overlapping myelodysplastic and myeloproliferative features, with poor overall …

Acute myeloid leukemia (AML) is a malignancy of the stem cell precursors of the myeloid
lineage. DNA methylation is an important DNA modification that regulates gene expression …