Mitochondria play a critical role in energy production, cell signalling and cell survival.
Defects in mitochondrial function contribute to the ageing process and ageing-related …

Radiation-induced liver injury (RILI) is a major complication of radiotherapy during treatment
for liver cancer and other upper abdominal malignant tumors that has poor pharmacological …

Aberrant redox signaling underlies the pathophysiology of many chronic metabolic
diseases, including type 2 diabetes (T2D). Methodologies aimed at rebalancing systemic …

Alveolar epithelial cell (AEC) mitochondrial dysfunction and apoptosis are important in
idiopathic pulmonary fibrosis and asbestosis. Sirtuin 3 (SIRT3) detoxifies mitochondrial …

Convincing evidence has emerged demonstrating that impairment of mitochondrial function
is critically important in regulating alveolar epithelial cell (AEC) programmed cell death …

During space travel astronauts are exposed to a variety of radiations, including galactic
cosmic rays composed of high-energy protons and high-energy charged (HZE) nuclei, and …

Radiation‐induced fibrosis (RIF) develops months to years after initial radiation exposure.
RIF occurs when normal fibroblasts differentiate into myofibroblasts and lay down aberrant …

Radiation-induced liver disease (RILD), also known as radiation hepatitis, is a serious side
effect of radiotherapy (RT) for hepatocellular carcinoma. The therapeutic dose of RT can …

Mitochondrial oxidative damage is hypothesized to contribute to the pathogenesis of chronic
cholestatic liver diseases. Melatonin, an indolamine synthesized in the pineal gland, shows …

Sirtuins are an evolutionary conserved family of NAD+-dependent protein lysine deacylases.
Mammals have seven Sirtuin isoforms, Sirt1–7. They contribute to regulation of metabolism …