Ferroptosis is a non-apoptotic cell death mechanism characterized by iron-dependent
membrane lipid peroxidation. Here, we review what is known about the cellular mechanisms …

Iron is a transition metal and essential constituent of almost all living cells and organisms. As
component of various metalloproteins it is involved in critical biochemical processes such as …

Iron is an essential mineral participating in different functions of the organism under
physiological conditions. Numerous biological processes, such as oxygen and lipid …

Lysosomal acidification is a key feature of healthy cells. Inability to maintain lysosomal acidic
pH is associated with aging and neurodegenerative diseases. However, the mechanisms …

Free radicals and other reactive species (RS) are thought to play an important role in many
human diseases. Establishing their precise role requires the ability to measure them and the …

Mitochondrial outer membrane permeabilization (MOMP) constitutes one of the major
checkpoint (s) of apoptotic and necrotic cell death. Recently, the permeabilization of yet …

It is now generally accepted that aging and eventual death of multicellular organisms is to a
large extent related to macromolecular damage by mitochondrially produced reactive …

Iron is an essential cofactor for important biological activities and biochemical reactions,
including the transport of oxygen via red blood cells and its reduction to water during …

The lysosomal compartment is essential for a variety of cellular functions, including the
normal turnover of most long-lived proteins and all organelles. The compartment consists of …

Iron is the most abundant transition metal in the earth's crust. It cycles easily between ferric
(oxidized; Fe (III)) and ferrous (reduced; Fe (II)) and readily forms complexes with oxygen …