L-Arginine (Arg) has been widely used due to its functional properties as a substrate for nitric
oxide (NO) generation. However, L-citrulline (CIT), whose main natural source is …

Introduction The efficacy and safety of arginine supplements in erectile dysfunction (ED)
remain debatable. Aim To assess the potential role of arginine supplements on ED as …

Purpose The current randomized, double-blind, placebo-controlled clinical trial addressed
the effects on penile erectile function of relatively high daily oral doses (6 g/day) of l-ARG for …

Background Erectile dysfunction is defined as inability to achieve or maintain penile erection
sufficient for sexual satisfaction. It is a serious problem that increases by age. The …

Pentoxifylline (PF) is a xanthine derivative drug primarily used to treat peripheral vascular
disorders. It is currently used in assisted reproductive technologies to enhance human …

Introduction: A synergistic effect of the combination therapy tadalafil plus L-Arginine is
conceivable in patients affected by erectile dysfunction (ED). Aim: To evaluate the …

Background Although nutraceutical-based treatments are often offered for erectile
dysfunction (ED), their efficacy remains doubtful, and the choice of one substance over the …

Abstract Purpose of Review To highlight and review encouraging preliminary studies behind
several alternative products and interventions for erectile dysfunction (ED). Recent Findings …

The meta‐analysis was performed to assess the efficacy and safety of daily oral L‐arginine
and phosphodiesterase type 5 inhibitors (PDE5Is) alone or combination in treating patients …

L-Arg is a nonessential amino acid but has many physiological roles. Accordingly, L-Arg has
been used in various fields, but there is only limited information available about its safety …