Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets
The arachidonic acid (AA) pathway plays a key role in cardiovascular biology,
carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified …
carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified …
Pharmacogenomics of impaired tyrosine kinase inhibitor response: lessons learned from chronic myelogenous leukemia
M Kaehler, I Cascorbi - Frontiers in Pharmacology, 2021 - frontiersin.org
The use of small molecules became one key cornerstone of targeted anti-cancer therapy.
Among them, tyrosine kinase inhibitors (TKIs) are especially important, as they were the first …
Among them, tyrosine kinase inhibitors (TKIs) are especially important, as they were the first …
Management of chronic myeloid leukaemia: current treatment options, challenges, and future strategies
Small molecule therapy is a critical component of targeted anticancer treatment, with
tyrosine kinase inhibitors (TKIs) being the first compounds to treat the clonal Chronic …
tyrosine kinase inhibitors (TKIs) being the first compounds to treat the clonal Chronic …
External evaluation of population pharmacokinetic models of imatinib in adults diagnosed with chronic myeloid leukaemia
Á Corral Alaejos, A Zarzuelo Castañeda… - British Journal of …, 2022 - Wiley Online Library
Aims Imatinib is considered the standard first‐line treatment in newly diagnosed patients
with chronic‐phase myeloid leukaemia (CML). Several imatinib population pharmacokinetic …
with chronic‐phase myeloid leukaemia (CML). Several imatinib population pharmacokinetic …
Cytochromes P450 2C8 and 3A catalyze the metabolic activation of the tyrosine kinase inhibitor masitinib
BD Latham, DS Oskin, RD Crouch… - Chemical research in …, 2022 - ACS Publications
Masitinib is a small molecule tyrosine kinase inhibitor under investigation for the treatment of
amyotrophic lateral sclerosis, mastocytosis, and COVID-19. Hepatotoxicity has been …
amyotrophic lateral sclerosis, mastocytosis, and COVID-19. Hepatotoxicity has been …
Therapeutic drug monitoring and pharmacogenetics to tune imatinib exposure in gastrointestinal stromal tumor patients: hurdles and perspectives for clinical …
S Gagno, CD Fratte, B Posocco, A Buonadonna… - …, 2023 - Taylor & Francis
Tweetable abstract Present evidence supports the use of intensified pharmacologic
monitoring of# imatinib including# TherapeuticDrugMonitoring and# PGx to improve …
monitoring of# imatinib including# TherapeuticDrugMonitoring and# PGx to improve …
Pharmacogenomics in the Nigerian population: the past, the present and the future
OO Bolaji, A Adehin, BA Adeagbo - Pharmacogenomics, 2019 - Taylor & Francis
The Nigerian population exhibits huge ethnic and genetic diversity, typical of African
populations, which can be harnessed for improved drug-response and disease …
populations, which can be harnessed for improved drug-response and disease …