Over the last five decades, a large body of evidence has accrued for structural and metabolic
brain alterations in schizophrenia. Here we provide an overview of these findings, focusing …

The human social brain is complex. Current knowledge fails to define the neurobiological
processes underlying social behaviour involving the (patho-) physiological mechanisms that …

Despite decades of research, the pathophysiology of bipolar disorder (BD) is still not well
understood. Structural brain differences have been associated with BD, but results from …

The profile of brain structural abnormalities in schizophrenia is still not fully understood,
despite decades of research using brain scans. To validate a prospective meta-analysis …

Physical activity (PA) may be therapeutic for people with severe mental illness (SMI) who
generally have low PA and experience numerous life style-related medical complications …

Concurrent transcranial magnetic stimulation and electroencephalography (TMS–EEG) has
emerged as a powerful tool to non-invasively probe brain circuits in humans, allowing for the …

The long‐term benefit‐to‐risk ratio of sustained antipsychotic treatment for schizophrenia
has recently been questioned. In this paper, we critically examine the literature on the long …

There is a growing understanding that pathological genetic variation and environmental
insults during sensitive periods in brain development have long-term consequences on …

Subcortical structures, which include the basal ganglia and parts of the limbic system, have
key roles in learning, motor control and emotion, but also contribute to higher-order …

Background Individuals at clinical high risk (CHR) who progress to fully psychotic symptoms
have been observed to show a steeper rate of cortical gray matter reduction compared with …